Results 71 to 80 of about 10,671 (149)

Dichloromethylation of enones by carbon nitride photocatalysis

, 2020
Small organic radicals are ubiquitous intermediates in photocatalysis and are used in organic synthesis to install functional groups and to tune electronic properties and pharmacokinetic parameters of the final molecule.
Antonietti, M., Kurpil, B., Mazzanti, S., Pieber, B., Savateev, A.   +4 more
core   +1 more source

Stereoselectivity and Structural Characterisation of an Imine Reductase (IRED) from Amycolatopsis orientalis [PDF]

, 2016
The imine reductase AoIRED from Amycolatopsis orientalis (Uniprot R4SNK4) catalyzes the NADPH-dependent reduction of a wide range of prochiral imines and iminium ions, predominantly with (S)-selectivity and with e.e.s of up to >99%. AoIRED displays up to
Aleku, Godwin, France, Scott P., Grogan, Gideon James, Hart, Sam J., Hussain, Shahed, Leipold, Friedemann, Man, Henry, Marchington, Rebecca, Toca-Gonzalez, Laura, Turkenburg, Johan P., Turner, Nicholas J.   +10 more
core   +1 more source

Crystal structure of 1-(1-chloroethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinium chloride

Acta Crystallographica Section E: Crystallographic Communications
1-(1-Chloroethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline was synthesized through the reaction of homoveratrylamine with racemic lactic acid. The formation of two enantiomers, RR and SS, was detected by performing X-ray diffraction analysis on their
Ziroat E. Urunbaeva, Kambarali K. Turgunov, Abdusalom Sh. Saidov, Valentina I. Vinogradova   +3 more
doaj   +1 more source

Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems

Beilstein Journal of Organic Chemistry, 2017
Background: 1,2,3,4-Tetrahydroisoquinolines (THIQs) are common motifs in alkaloids and in medicinal chemistry. Synthetic access to THIQs via the Pomeranz–Fritsch–Bobbit (PFB) methodology using mineral acids for deactivated, electron-poor aromatic systems,
Marco Mottinelli, Mathew P. Leese, Barry V. L. Potter   +2 more
doaj   +1 more source

4-[(2,4-Dimethylthiazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

Acta Crystallographica Section E, 2010
In the title isoquinolinedione derivative, C16H16N2O3S, the piperidine ring in the tetrahydroisoquinoline ring system adopts a distorted envelope conformation.
Hoong-Kun Fun, Jia Hao Goh, Haitao Yu, Yan Zhang   +3 more
doaj   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

4-[(2,5-Dimethyl-1,3-thiazol-4-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

Acta Crystallographica Section E, 2010
In the title isoquinolinedione compound, C16H16N2O3S, the piperidine ring in the tetrahydroisoquinoline ring system adopts a half-boat conformation. The essentially planar thiazole ring [maximum deviation = 0.007 (2) Å] makes
Hoong-Kun Fun, Jia Hao Goh, Haitao Yu, Yan Zhang   +3 more
doaj   +1 more source

Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations [PDF]

, 2016
A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
O'Donnell, Martin J., Scott, William L., Zhou, Ziniu   +2 more
core   +2 more sources

Using MD Simulations to Understand the Impact of Directed Evolution on Oxygen Affinity in Amine Oxidases

ChemistryOpen, Volume 15, Issue 4, April 2026.
A combination of experimental and computational experiments has been used to understand oxygen needs for evolved amine oxidase enzymes. Two variants of amine oxidase from Aspergillus niger were shown to have different oxygen requirements in the oxidation of a model substrate, with molecular dynamics simulations used to model the differences between the
Christopher R. Field, Rowan Lindeque, Jonathan P. Dolan, Julie Østerby Madsen, Sam Hay, Nicholas J. Turner, John M. Woodley, Sebastian C. Cosgrove   +7 more
wiley   +1 more source

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates

Beilstein Journal of Organic Chemistry, 2014
Nucleophilic trapping of iminium salts generated via oxidative functionalisation of tertiary amines is well established with stabilised carbon nucleophiles.
Joshua P. Barham, Matthew P. John, John A. Murphy   +2 more
doaj   +1 more source