Results 171 to 180 of about 4,486 (199)
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Synthesis of novel tetrahydroisoquinoline bronchodilators
Bioorganic & Medicinal Chemistry Letters, 2010The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties.
Maria F, Dalence-Guzmán +4 more
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1-benzyl-1, 2, 3, 4-tetrahydroisoquinolines
Journal of Pharmaceutical Sciences, 1967The syntheses of 1-benzyl-1,2, 3, 4-tetrahydro-isoquinolines, particularly phenolic derivatives, are described. Preliminary pharmacological data also are reported.
J, Sam, A J, Bej
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Pictet–Spengler tetrahydroisoquinoline synthesis
2009Tetrahydroisoquinolines from condensation of β-arylethylamines and carbonyl compounds followed by cyclization.
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Bis-tetrahydroisoquinoline derivatives
European Journal of Medicinal Chemistry, 2010Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.
Wouters, Johan +4 more
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A new tetrahydroisoquinoline synthesis
Journal of Heterocyclic Chemistry, 1970AbstractCyclization of 2‐vinylbenzylamines affords 1,2,3,4‐tetrahydroisoquinolines. The synthesis of the vinylbenzylamines from benzhydrols or isoindolones is described.
K. Freter, E. Dubois, A. Thomas
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New compounds: N-substituted tetrahydroisoquinolines
Journal of Pharmaceutical Sciences, 1967The Mannich, sodium borohydride reduction, and esterification reactions were utilized for the preparation of several N-substituted tetrahydroisoquinolines. Aminolysis of ethyl cyanoacetate with tetrahydroisoquinoline provided the corresponding cyanoacetamide.
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Tropylium-Promoted Oxidative Functionalization of Tetrahydroisoquinolines
The Journal of Organic Chemistry, 2018Structural modification of the tetrahydroisoquinoline (THIQ) framework is of significant interest to organic chemists due to its central role in heterocyclic and medicinal chemistry. Here we demonstrate an efficient metal-free method for the oxidative functionalization of THIQs at the C1 position, which is amenable to a diverse range of C-C coupling ...
Giulia Oss +4 more
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PREPARATION OF 1,7-DISUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINES
Synthetic Communications, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Jag P. Heer +2 more
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[Tetrahydroisoquinoline and parkinsonism].
Rinsho shinkeigaku = Clinical neurology, 1990In squirrel monkeys (n = 13), 20 mg/kg/day of TIQ was injected subcutaneously for 43 to 104 days. Behavioral scores of motor disturbance were analysed; ranging from 20/45 to 30/45 (mean 27.8 +/- 4.18). Dopamine, total biopterine and tyrosine hydroxylase (TH) were decreased in the substantia nigra of TIQ treated monkeys compared to saline treated ...
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Accumulation of a Tetrahydroisoquinoline in Phenylketonuria
Science, 19793′,4′-Deoxynorlaudanosolinecarboxylic acid (DNLCA), a tetrahydroisoquinoline derived from dopamine and phenylpyruvic acid, has been detected by computerized mass fragmentography in urine of phenylketonuric children and in urine and brain of rats with experimentally induced hyperphenylalaninemia.
J M, Lasala, C J, Coscia
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