The macronuclear genomic landscape within Tetrahymena thermophila. [PDF]
Microb Genom, 2023 AbstractThe extent of intraspecific genomic variation is key to understanding species evolutionary history, including recent adaptive shifts. Intraspecific genomic variation remains poorly explored in eukaryotic microorganisms, especially in the nuclear dimorphic ciliates, despite their fundamental role as laboratory model systems and their ecological ...
Derelle R +6 more
europepmc +5 more sources
A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila. [PDF]
PLoS ONE, 2014 Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components.
Graeme J M Cowan +7 more
doaj +8 more sources
Metabolomics’ Change Under β-Cypermethrin Stress and Detoxification Role of CYP5011A1 in Tetrahymena thermophila [PDF]
MetabolitesBackground: β-cypermethrin (β-CYP) exhibits high toxicity to aquatic organisms and poses significant risks to aquatic ecosystems. Tetrahymena thermophila, a protozoa widely distributed in aquatic environments, can tolerate high concentrations of β ...
Wenyong Zhang +4 more
doaj +2 more sources
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism. [PDF]
PLoS ONE, 2023 Tetrahymena are ciliated protists that have been used to study the effects of toxic chemicals, including anticancer drugs. In this study, we tested the inhibitory effects of six pyrimidine analogs (5-fluorouracil, floxuridine, 5'-deoxy-5-fluorouridine, 5-
Zander Harpel +7 more
doaj +2 more sources
Septins Stabilize Mitochondria in Tetrahymena thermophila [PDF]
Eukaryotic Cell, 2008 ABSTRACT We describe phylogenetic and functional studies of three septins in the free-living ciliate Tetrahymena thermophila . Both deletion and overproduction of septins led to vacuolization of mitochondria, destabilization of the nuclear envelope, and increased autophagy.
Dorota Włoga +3 more
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Putrescine biosynthesis in Tetrahymena thermophila [PDF]
Biochemical Journal, 1984 The putrescine-biosynthesis pathway in Tetrahymena thermophila was delineated by studying crude extracts prepared from exponentially growing cultures. A pyridoxal phosphate-stimulated ornithine decarboxylase activity competitively inhibited by putrescine was detected. CO2 was also liberated from L-arginine, but analyses by t.l.c.
KM Yao, W.F. Fong, Stephen F. Ng
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Tetrahymena thermophila glutathione-S-transferase superfamily: an eco-paralogs gene network differentially responding to various environmental abiotic stressors and an update on this gene family in ciliates [PDF]
Frontiers in GeneticsGlutathione S-transferases constitute a superfamily of enzymes involved mainly, but not exclusively, in the detoxification of xenobiotic compounds that are considered environmental pollutants.
Ruth Ortega +2 more
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Snf2 Proteins Are Required to Generate Gamete Pronuclei in Tetrahymena thermophila [PDF]
Microorganisms, 2022 During sexual reproduction/conjugation of the ciliate Tetrahymena thermophila, the germinal micronucleus undergoes meiosis resulting in four haploid micronuclei (hMICs).
Yasuhiro Fukuda +3 more
doaj +2 more sources
Sfr1, a
mSphere, 2016 Basal bodies are essential microtubule-based structures that template, anchor, and orient cilia at the cell surface. Cilia act primarily in the generation of directional fluid flow and sensory reception, both of which are utilized for a broad spectrum of
Westley Heydeck +4 more
doaj +2 more sources
Protection of Grouper Against Cryptocaryon irritans by Immunization With Tetrahymena thermophila and Protective Cross-Reactive Antigen Identification [PDF]
Frontiers in Immunology, 2022 Vaccination is an effective method to prevent Cryptocaryon irritans infection. Although some vaccines have been developed, large-scale production of these vaccines is costly.
Zequan Mo +9 more
doaj +2 more sources