Results 61 to 70 of about 13,833 (240)

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Phylogenomic analysis of integral diiron membrane histidine motif-containing enzymes in ciliates provides insights into their function and evolutionary relationships [PDF]

, 2017
The Integral Membrane Histidine Motif-containing Enzymes (IMHME) are a class of binuclear non-heme iron proteins widely distributed among prokaryotes and eukaryotes.
Cid, Nicolás Gonzalo, Elguero, María Eugenia, Montes, María Guadalupe, Nudel, Berta Clara, Nusblat, Alejandro David, Sánchez Granel, María Luz   +5 more
core   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

Induction of oxidative stress, apoptosis and DNA damage by koumine in Tetrahymena thermophila.

PLoS ONE, 2019
Koumine is a component of the Chinese medicinal herb Gelsemium elegans and is toxic to vertebrates. We used the ciliate Tetrahymena thermophila as a model to evaluate the toxic effects of this indole alkaloid in eukaryotic microorganisms.
Qiao Ye, Chaonan Zhang, Zhenlu Wang, Yongyong Feng, Aiguo Zhou, Shaolin Xie, Qiong Xiang, Enfeng Song, Jixing Zou   +8 more
doaj   +1 more source

Equilibrium properties and force-driven unfolding pathways of RNA molecules

, 2009
The mechanical unfolding of a simple RNA hairpin and of a 236--bases portion of the Tetrahymena thermophila ribozyme is studied by means of an Ising--like model.
A. Imparato, A. Pelizzola, M. Müller, M. Zamparo   +3 more
core   +1 more source

Unraveling the Carcinogenic Mechanisms of Food Contaminants: An Integrated in Silico Framework Combining Network Toxicology, Machine Learning, and Molecular Docking

Journal of Food Science, Volume 90, Issue 11, November 2025.
ABSTRACT Food contamination poses a significant global health threat with carcinogenic potential, though the molecular pathways connecting contaminants to cancer remain poorly understood. This study sought to identify key molecular targets mediating the carcinogenic effects of nine prevalent dietary contaminants: glyphosate, perfluorooctane sulfonate ...
Bangsheng Chen, Maomao Li, Yi Gu, Wenzhu Lou, Shuaishuai Huang, Feiyan Mao, Lian Tan, Zhiyan Wang   +7 more
wiley   +1 more source

An evolutionarily conserved phosphatidate phosphatase maintains lipid droplet number and endoplasmic reticulum morphology but not nuclear morphology

Biology Open, 2017
Phosphatidic acid phosphatases are involved in the biosynthesis of phospholipids and triacylglycerol, and also act as transcriptional regulators. Studies to ascertain their role in lipid metabolism and membrane biogenesis are restricted to Opisthokonta ...
Anoop Narayana Pillai, Sushmita Shukla, Abdur Rahaman   +2 more
doaj   +1 more source

A Small Family of Elements with Long Inverted Repeats is Located Near Sites of Developmentally Regulated DNA Rearrangement in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1994
Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans. The micronuclear junctions and the macronuclear product of a developmentally regulated DNA rearrangement in ...
Berger, Patricia J., Catt, Diana M., Ellingson, Jay Lee Edward, Karrer, Kathleen M., Wells, John M.   +4 more
core   +1 more source

Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]

, 1991
The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K, Malik, F, Ohashi, S, Okuno, M, Shimizu, T, Toyoshima, YY, Vale, RD   +6 more
core   +2 more sources

The Imbalance of Nature: The Role of Species Environmental Responses for Community Stability

Ecology Letters, Volume 28, Issue 10, October 2025.
This study shows that the distribution of species' fundamental responses to environmental change, quantified by a new metric, imbalance, is a key driver of ecological stability. In a large microcosm experiment, lower imbalance predicted greater temporal stability, independently of species richness. Our findings highlight the predictive power of species'
Francesco Polazzo, Til Hämmig, Owen L. Petchey, Frank Pennekamp   +3 more
wiley   +1 more source