Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]
Molecules, 2020 A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Lília I. L. Cabral +5 more
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Bangladesh Journal of Pharmacology, 2015 Seven novel dispiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain
Mukesh Kumar Kumawat, Dipak Chetia
doaj +5 more sources
In silico modeling of tetraoxane-8-aminoquinoline hybrids active against Plasmodium falciparum [PDF]
Beni-Suef University Journal of Basic and Applied Sciences, 2020 Background Quantitative structure-activity relationships (QSAR) is a technique that is used to produce a model that connects biological activities of compounds to their chemical structures, and molecular docking is a technique that reveals the binding ...
Aliyu Wappah Mahmud +2 more
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Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2008 Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds.
IGOR M. OPSENICA +4 more
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Structure, Properties, and Biomedical Activity of Natural Sweeteners Steviosides: An Update. [PDF]
Food Sci NutrStevioside is a natural sweetener with the characteristics of low calorie and high sweetness. It consists of a wide variety of monomers involved in several biological processes. It has been widely used in the food and pharmaceutical industries. As a substitute for sugar, stevioside also shows good pharmacological activities.
Wang A +7 more
europepmc +2 more sources
Hybrid Molecules as Efficient Drugs against Multidrug-Resistant Malaria Parasites. [PDF]
ChemMedChemAmong hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Robert A +6 more
europepmc +2 more sources
Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes [PDF]
Journal of the Serbian Chemical Society, 2003 Mixed tetraoxanes of the 4-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and antimycobacterials.
BOGDAN A. SOLAJA +3 more
doaj +5 more sources
New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum [PDF]
Malaria Journal, 2018 Background The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
Lis Lobo +7 more
doaj +2 more sources
Tetraoxanes as inhibitors of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and anti-cancer molecules [PDF]
Journal of the Serbian Chemical Society, 2015 New cyclohexylidene 1,2,4,5-tetraoxanes with polar guanidine and urea based groups were synthesized and evaluated for antimalarial activity against chloroquine resistant and susceptible Plasmodium falciparum strains.
Opsenica Dejan M. +6 more
doaj +3 more sources
Elicitation effects of synthetic 1,2,4,5-tetraoxane and 2,5-diphenyltiophene in shoot cultures of two Nepeta species [PDF]
Journal of the Serbian Chemical Society, 2016 The present study was aimed to investigate the elicitation possibility of the main secondary metabolites production in Nepeta cataria L. and N. pannonica L.
Dmitrović Slavica +7 more
doaj +3 more sources