Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes [PDF]
Journal of the Serbian Chemical Society, 2003 Mixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl- spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and antimycobacterials.
Opsenica Dejan M. +3 more
doaj +5 more sources
SYNTHESIS AND PHYTOTOXIC PROFILE OF A NEW TETRAOXANE DESIGNED FROM A COMMERCIAL AUXIN [PDF]
Química Nova, 2020 Modern agriculture relies on the massive use of agrochemicals, including herbicides. Despite their effectiveness, a continuous use of herbicides sharing the same target has resulted in the selection of weed biotypes resistant to such chemicals.
Isabel V. Antolínez +4 more
doaj +4 more sources
Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores [PDF]
Journal of the Serbian Chemical Society, 2008 Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds.
IGOR M. OPSENICA +4 more
doaj +5 more sources
Tetraoxanes as inhibitors of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and anti-cancer molecules [PDF]
Journal of the Serbian Chemical Society, 2015 New cyclohexylidene 1,2,4,5-tetraoxanes with polar guanidine and urea based groups were synthesized and evaluated for antimalarial activity against chloroquine resistant and susceptible Plasmodium falciparum strains.
Opsenica Dejan M. +6 more
doaj +3 more sources
New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum [PDF]
Malaria Journal, 2018 Background The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
Lis Lobo +7 more
doaj +2 more sources
Interaction between the Antimalarial Drug Dispiro-Tetraoxanes and Human Serum Albumin: A Combined Study with Spectroscopic Methods and Computational Studies. [PDF]
ACS Omega, 2020 Yadav P +4 more
europepmc +2 more sources
Bangladesh Journal of Pharmacology, 2015 Seven novel dispiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain
Mukesh Kumar Kumawat, Dipak Chetia
doaj +3 more sources
Elicitation effects of synthetic 1,2,4,5-tetraoxane and 2,5-diphenyltiophene in shoot cultures of two Nepeta species [PDF]
Journal of the Serbian Chemical Society, 2016 The present study was aimed to investigate the elicitation possibility of the main secondary metabolites production in Nepeta cataria L. and N. pannonica L.
Dmitrović Slavica +7 more
doaj +3 more sources
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. [PDF]
ACS Med Chem Lett, 2021 Woodley CM +11 more
europepmc +3 more sources
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and Cancer. [PDF]
ChemMedChem, 2022 Hybrid power: New artemisinin‐ and synthetic peroxide‐based hybrids, highly active in vitro against leukemia cell lines and SARS‐CoV‐2, were synthesized. Remarkably, the most active anti‐cancer hybrid compounds are also the most potent and selective against SARS‐CoV‐2. Abstract The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
Herrmann L +13 more
europepmc +2 more sources