Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. [PDF]
ACS Med Chem Lett, 2021 Woodley CM +11 more
europepmc +3 more sources
Interaction between the Antimalarial Drug Dispiro-Tetraoxanes and Human Serum Albumin: A Combined Study with Spectroscopic Methods and Computational Studies. [PDF]
ACS Omega, 2020 Yadav P +4 more
europepmc +2 more sources
Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials. [PDF]
Mol Med, 2012 Copple IM +13 more
europepmc +3 more sources
Assessment of the antimalarial potential of tetraoxane WR 148999. [PDF]
The American journal of tropical medicine and hygiene, 2000 The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between artemisinin and chloroquine, these drug combination data imply that WR 148999 and artemisinin may not share
Jonathan L. Vennerstrom +7 more
openalex +3 more sources
The Impact of Activity‐Based Protein Profiling in Malaria Drug Discovery
ChemMedChem, Volume 17, Issue 14, July 19, 2022., 2022 Activity‐based protein profiling has impacted several biological research areas by providing functional fingerprints of enzymatic activity in complex proteomes. We discuss the main achievements of ABPP in the field of malaria research, including characterization of pathologically‐relevant enzymes, target and mechanism deconvolution of antimalarials ...
Luís A. R. Carvalho +1 more
wiley +1 more source
Endoperoxides as Antimalarials: Development, Structural Diversity, and Pharmacodynamic Aspects of 1,2,4,5-Tetraoxane-Based Structural Scaffolds [PDF]
SynOpenUpendra Kumar Patel +2 more
doaj +2 more sources
Medicinal Research Reviews, Volume 41, Issue 6, Page 3023-3061, November 2021., 2021 Abstract The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin‐type compounds toward inflammatory and autoimmune diseases ...
Thomas Efferth, Franz Oesch
wiley +1 more source
Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics
Advanced Science, Volume 8, Issue 16, August 18, 2021., 2021 This review summarizes the recent progress made on metal‐coordinated supramolecular nanomedicines for cancer theranostic by classifying the coordination metal ions in the order of periodic table. Especially, the superiority of the tumor‐responsive nanomedicines for in vivo coordinated self‐assembling cancer theranostic is discussed, with an emphasis on
Jiating Xu +7 more
wiley +1 more source
Small Science, Volume 1, Issue 3, March 2021., 2021 The preparation strategies of functional nucleic acid (FNA)‐decorated spherical nanoparticles (SNPs) are summarized with the focus on the current applications of aptamer‐, i‐motif‐, DNAzyme‐, antisense oligonucleotide (ASO)‐, and CpG oligodeoxynucleotide (ODN)‐decorated SNPs in cancer therapy, involved in targeted drug delivery, controlled drug release,
Min Zhu, Shan Wang
wiley +1 more source