Results 31 to 40 of about 398 (143)

Efforts Made to Eliminate Drug‐Resistant Malaria and Its Challenges

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Since 2000, a good deal of progress has been made in malaria control. However, there is still an unacceptably high burden of the disease and numerous challenges limiting advancement towards its elimination and ultimate eradication. Among the challenges is the antimalarial drug resistance, which has been documented for almost all antimalarial drugs in ...
Wote Amelo, Eyasu Makonnen, Jane Hanrahan   +2 more
wiley   +1 more source

7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity [PDF]

Journal of the Serbian Chemical Society, 2004
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains,
Opsenica Igor, Terzić Nataša A., Opsenica Dejan M., Milhous Wilbur K., Šolaja Bogdan A.   +4 more
doaj   +3 more sources

Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi

Agrochemicals, 2023
The search for new classes of fungicides has long been important in plant protection due to the development of fungal resistance to currently used agrochemicals. Organic peroxides have long been regarded as exotic and unstable compounds. The discovery of
Ivan A. Yaremenko, Peter S. Radulov, Yulia Yu. Belyakova, Dmitrii I. Fomenkov, Vera A. Vil’, Maria A. Kuznetsova, Valentina N. Demidova, Alexei P. Glinushkin, Alexander O. Terent’ev   +8 more
doaj   +1 more source

Steroidal Tetraoxanes - New Class of Antitumor Compounds

Proceedings of The 3rd International Electronic Conference on Synthetic Organic Chemistry, 1999
Cholic acid derived steroidal tetraoxanes possessing methyl ester, carboxylic acid, primary and secondary amide termini were synthesised and their in vitro antitumor activity against Fem-X and HeLa cell cultures was determined. IC50 range between 3.1 and 166 M. Five out of seven tested compounds exhibited cell rounding and / or apoptic activity.
Bogdan A. Šolaja, Dejan Opsenica, Gabriella Pòcsfalvi, Zorica D. Juranić   +3 more
openalex   +2 more sources

THEORETICAL STUDIES ON DIACETONEDIPEROXIDE DERIVATIVES AND COMPARISONS WITH OTHER MULTI-PEROXIDIC COMPOUNDS [PDF]

Química Nova
Diacetonediperoxide (DADP) derivatives were investigated with density functional theory (DFT) methods at the DFT-B3LYP and M06-2X/6-311++G (d, p) levels and were also compared with other multi-peroxidic compounds.
Zongcheng Miao, Junmei Li, Guoliang Fan, Luan Yi   +3 more
doaj   +2 more sources

Synthesis and initial testing of novel antimalarial and antitubercular isonicotinohydrazides

Results in Chemistry, 2022
Malaria and tuberculosis (TB) though curable and preventable, remain serious public health problems globally, with devastating consequences. Co-infection of these two deadly diseases worsens the situation and particularly makes treatment very difficult ...
Richard K. Amewu, Crystal F. Ade, Isaac Darko Otchere, Portia Morgan, Dorothy Yeboah-Manu   +4 more
doaj   +1 more source

418 POSTER Investigation of some tetraoxanes as potential antitumour agents

, 2007
Željko Žižak, Dejan Opsenica, Bogdan A. Šolaja, Z.D. Juranic   +3 more
openalex   +3 more sources

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

Bioorganic & Medicinal Chemistry, 2018
A series of aryl carboxamide and benzylamino dispiro 1,2,4,5-tetraoxane analogues have been designed and synthesized in a short synthetic sequence from readily available starting materials. From this series of endoperoxides, molecules with in vitro IC50s versus Plasmodium falciparum (3D7) as low as 0.84 nM were identified.
Paul M. O' Neill, Paul A. Stocks, Sunil Sabbani, Natalie L. Roberts, Richard K. Amewu, Emma R. Shore, Ghaith Aljayyoussi, Íñigo Angulo‐Barturen, María Belén, Jiménez-Díaz, Santiago Ferrer, Maria Santos Martínez, Brice Campo, Raman Sharma, Susan A. Charman, Eileen Ryan, Gong Chen, David M. Shackleford, Jill Davies, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward   +21 more
openalex   +4 more sources

SYNTHESIS AND PHYTOTOXIC PROFILE OF A NEW TETRAOXANE DESIGNED FROM A COMMERCIAL AUXIN [PDF]

Química Nova
Modern agriculture relies on the massive use of agrochemicals, including herbicides. Despite their effectiveness, a continuous use of herbicides sharing the same target has resulted in the selection of weed biotypes resistant to such chemicals.
Isabel V. Antolínez, Luiz C. A. Barbosa, Célia R. A. Maltha, Gustavo A. M. M. Pereira, Antônio A. Silva   +4 more
doaj   +2 more sources

Antitumor Activity of Artemisinin and Its Derivatives: From a Well‐Known Antimalarial Agent to a Potential Anticancer Drug

BioMed Research International, Volume 2012, Issue 1, 2012., 2012
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells. Artemisinin and its analogs are naturally occurring antimalarials which have shown potent anticancer activity.
Maria P. Crespo-Ortiz, Ming Q. Wei, Masa-Aki Shibata   +2 more
wiley   +1 more source