Synthesis of some novel steroidal 1,2,4,5-tetraoxanes
RSC Advances, 2015 A facile synthesis of A-ring manipulated C-20 methyl carboxylate steroid derivative with unsymmetrical dispiro 1,2,4,5-tetraoxanes has been focused herein via acid catalyzed cyclocondensation of bis-epidioxy ketone.
Archana M. Das, Manash P. Hazarika
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Chemometric methods in antimalarial drug design from 1,2,4,5-tetraoxanes analogues
SAR and QSAR in Environmental Research, 2020 A set of 23 steroidal 1,2,4,5-tetraoxane analogues were studied using quantum-chemical method (B3LYP/6-31 G*) and multivariate analyses (PCA, HCA, KNN and SIMCA) in order to calculate the properties and correlate them with antimalarial activity (log RA) against Plasmodium falciparum clone D-6 from Sierra Leone. PCA results indicated 99.94% of the total
E.B. Costa +9 more
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A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy
Advanced NanoBiomed Research, Volume 4, Issue 2, February 2024.In this review, the latest progression of essential metal‐ion‐based nanomedicine for tumor therapy is summarized, existing challenges are addressed, and possible directions of such therapeutic strategies are proposed. Such information benefits readers a general awareness for current research status and implication of the future clinical applications ...
Lin Weng, Xin Chen
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The growth of tetraoxane crystals from acetone solutions [PDF]
Journal of Crystal Growth, 1980 Abstract The growth mechanism of tetraoxane whiskers is investigated. The defect arrangement in the crystal is examined by X-ray topography. Whiskers can grow in the absence of any axia 1 dislocations. The nature of the crystal-solution interfaces is discussed.
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Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2 [PDF]
, 2022 Ryan da Silva Ramos +5 more
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Molecular and Crystal Structure, Spectroscopy, and Photochemistry of a Dispiro Compound Bearing the Tetraoxane Pharmacophore [PDF]
, 2023 Patrícia S. M. Amado +7 more
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Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials
Tetrahedron, 2016 Abstract An efficient route to the synthesis of potent antimalarial aryloxy 1,2,4,5-tetraoxanes is described that permits parallel synthesis for Structure–Activity Relationship (SAR) investigations. Brief details of the in vitro and in vivo antimalarial evaluation are included which enables identification of antimalarial leads for further development.
O' Neill, Paul M +11 more
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Identification of Antischistosomal Leads by Evaluating Bridged 1,2,4,5-Tetraoxanes, Alphaperoxides, and Tricyclic Monoperoxides [PDF]
, 2012 Katrin Ingram +5 more
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Cover Feature: Catalyst Development for the Synthesis of Ozonides and Tetraoxanes Under Heterogeneous Conditions: Disclosure of an Unprecedented Class of Fungicides for Agricultural Application (Chem. Eur. J. 21/2020) [PDF]
, 2020 Ivan A. Yaremenko +8 more
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Lewis Acids and Heteropoly Acids in the Synthesis of Organic Peroxides. [PDF]
Pharmaceuticals (Basel), 2022 Yaremenko IA +5 more
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