Sex Differences in the Adverse Effects of Nicotine-Free E-Cigarettes on Myocardial Oxygen Supply and Demand Balance: A Preclinical Rat Study. [PDF]
J Am Heart AssocRafiei D +6 more
europepmc +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Plant phenology, while genetically determined, is highly responsive to environmental drivers such as soil nutrient availability and disturbance. As an essential micronutrient, zinc (Zn) plays a critical role in plant development by regulating key processes including RNA
Qiuhua Li +10 more
wiley +1 more source
Biocompatibility With Osteogenic Potential of Premixed Bioceramic Cements for Use in Apical Surgery
Australian Endodontic Journal, EarlyView.ABSTRACT This study investigated the biocompatibility and osteogenic potential of premixed bioceramic cements (PBCs)—CeraPutty, EndoCEM MTA Premixed, Well‐Root PT, and One‐Fil PT Injectable—as alternatives to mineral trioxide aggregate for retrograde filling in endodontic microsurgery.
Yesol Kim +5 more
wiley +1 more source
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8
Brain Pathology, EarlyView.We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren +5 more
wiley +1 more source
Correction: Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells. [PDF]
J NeuroinflammationRuan Z +7 more
europepmc +1 more source
Cancer Science, EarlyView.Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi +11 more
wiley +1 more source
The FEBS Journal, EarlyView.Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello +9 more
wiley +1 more source
MicroRNA-663a upregulation upon ARID1A depletion promotes the growth and migration of esophageal cancer cells by targeting FKBP8. [PDF]
Transl Cancer ResLiao H, Ren C, Jiang Y, Wang F, Dai Y.
europepmc +1 more source
Ultrafast python‐integrated single‐entity electrochemical sensor for detecting glycated albumin
The FEBS Journal, EarlyView.Traditional biosensors suffer from the fact that recognition receptors are immobilised and that they denature on electrodes. Instead here we use receptors freely in solution, minimising surface compression and preserving activity to boost signal efficiency. Python‐driven processing turns the electrochemical response into a rapid, robust readout.
Zihni Onur Uygun
wiley +1 more source
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
The FEBS Journal, EarlyView.This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source