Results 81 to 90 of about 132,391 (265)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Qualidade fisiológica de sementes de soja em função da adubação com fósforo, molibdênio e cobalto = Soybean seed physiological quality in function of phosphorus, molybdenum and cobalt fertilization

Acta Scientiarum. Agronomy, 2006
Com o objetivo de avaliar o efeito da aplicação de doses de fósforo, molibdênio e cobalto na qualidade fisiológica de sementes da geração subseqüente na cultura da soja, foi desenvolvido um experimento em condições de campo, em Latossolo Vermelho ...
Claudio Augusto Guerra, Marlene Estevão Marchetti, Antonio Dias Robaina, Luiz Carlos Ferreira de Souza, Manoel Carlos Gonçalves, José Oscar Novelino   +5 more
doaj  

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Upcycling Water Pollutants Into Long‐Chain Polymers via Synergistic Interfacial Dechlorination and Organic Radical Stabilization

Angewandte Chemie, EarlyView.
HEO‐regulated electronic structure drives nonradical PI activation, promoting ETP‐mediated polymerization of 4CP into high‐molecular‐weight products with enhanced surface enrichment. Concurrent dechlorination occurs via radical coupling and •OHads attack, enabling efficient carbon retention and selective product evolution at the liquid–solid interface.
Ziwei Yao, Yidi Chen, Penghui Shao, Jian Liu, Xiaodan Wang, Kunsheng Hu, Xubiao Luo, Nanqi Ren, Xiaoguang Duan   +8 more
wiley   +2 more sources

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

Effect of pretreatments on the viability of seeds from five Passiflora species

Revista de Ciencias Agrícolas
Given the economic importance of Passiflora species in Colombia and the low germination rate caused by their marked dormancy, it is necessary to optimize rapid and accurate quality control protocols that guarantee viable seeds for agriculture. This study
Jesús David Quintero-Caleño, Yordan Arley Palencia-Delgado, Pedro Isaac Salcedo-Garcia, Seir Antonio Salazar-Mercado   +3 more
doaj   +1 more source

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, EarlyView.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source

Germinación asimbiótica de semillas y desarrollo in vitro de plántulas de Cattleya mendelii Dombrain (Orchidaceae) Asymbiotic seed germination and in vitro seedling development of Cattleya mendelii Dombrain (Orchidaceae)

Acta Agronómica, 2012
Cattleya mendelii es una orquídea endémica de Colombia de gran valor ornamental que se encuentra en peligro de extinción a causa de la recolección masiva y a la destrucción de sus hábitats naturales por la acción antrópica.
Seir Antonio Salazar-Mercado
doaj  

Adaptation of the tetrazolium test method for estimating the viability of sorghum seeds

Journal of Seed Science
The tetrazolium test is part of internal programs of seed quality control because it allows a quick, reliable and accurate assessment of seed viability.
Tereza Cristina de Carvalho, Camila Ribeiro de Souza Grzybowski, Osvaldo de Castro Ohlson, Maristela Panobianco   +3 more
doaj   +1 more source