Results 131 to 140 of about 326,662 (301)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

open access: yesThe FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner   +13 more
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

open access: yesHepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura   +11 more
wiley   +1 more source

Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance

open access: yesPlant Biotechnology Journal, EarlyView.
Peptide Power: VR18 & KG18 Shield Tobacco from Bacterial Attack. A schematic shows how antimicrobial peptides VR18 and KG18 fight Pseudomonas syringae—bursting bacterial membranes and boosting disease resistance in transgenic tobacco, without harming plant health.
Karishma Biswas   +17 more
wiley   +1 more source

The Transcription Factors NFYA1 and GBF3 Jointly Regulate CHS2 to Promote Tangeretin Accumulation and Cold Tolerance in Citrus

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Tangeretin has been known as a polymethoxylated flavone conferring both phytoprotection and nutraceutical value, but cryoprotective roles and molecular regulation of tangeretin under abiotic stresses remain largely unexplored. In this study, we demonstrated that cold treatment led to greater accumulation of tangeretin and upregulation of ...
Peng Xiao   +8 more
wiley   +1 more source

Calmodulin‐Like Protein MfCML50 Interacts With Carveol Dehydrogenase in Medicago falcata to Regulate Cold Tolerance Through Mediating ROS Homeostasis

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Low temperature triggers Ca2+ signalling and reprogramming of gene expression and metabolism in plants. However, how the Ca2+ signal is transduced to the downstream metabolic pathways remains unknown. The involvement of a cold‐induced calmodulin‐like protein, MfCML50, from Medicago falcata in regulation of cold tolerance was examined in the ...
Bohao Geng   +6 more
wiley   +1 more source

Trans‐QTL Alliance of HKT1 and PHL7 Modulate Salinity Stress Tolerance and Enhance Crop Yield Endurance

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Salinity stress can cause significant yield losses in crops because of its major impact on reproductive success. The complexity of salinity stress responses, particularly their tissue‐ and cell‐specific regulation, continues to challenge the translation of molecular insights into tangible crop yield improvements.
Jitendra K. Mohanty   +8 more
wiley   +1 more source

Alternaria alternata Effector Aa593 Promotes Virulence by Hijacking the CmNAC29‐Mediated Abscisic Acid Biosynthesis Pathway in Chrysanthemum

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT The interaction between plants and pathogens has long been an actively researched field of plant immunity. In this study, we found an Aa593/CmNAC29‐CmNCED3 module associated with the interaction between chrysanthemum and the fungal pathogen Alternaria alternata.
Boxiao Dong   +10 more
wiley   +1 more source

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