Results 41 to 50 of about 10,686 (159)

Vital dye reaction and granule localization in periplasm of Escherichia coli.

PLoS ONE, 2012
BackgroundTetrazolium salts are widely used in biology as indicators of metabolic activity - hence termed vital dyes - but their reduction site is still debated despite decades of intensive research.
Liyan Ping, Despoina A I Mavridou, Eldon Emberly, Martin Westermann, Stuart J Ferguson   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Ternary ion-association complexes of cobalt with 4-(2-pyridylazo)resorcinol and tetrazolium salts

Acta Chimica Slovenica, 2014
The formation of ternary ion-association complexes of Co(II) with 4-(2-pyridylazo)resorcinol (PAR) and tetrazolium salts (TS) – (3-(4,5-dimethylThiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and 3-(2-naphtyl)-2,5-diphenyl-2H-tetrazolium chloride
Vanya Dimitrova Lekova, Vidka Vasileva Divarova, Petya Vasileva Racheva, Kirila Trifonova Stojnova, Atanas Nikolov Dimitrov   +4 more
doaj  

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Effect of growth media on the MTT colorimetric assay in bacteria.

PLoS ONE, 2019
Reduction of tetrazolium salts to colored formazan products by metabolically active cells is widely used for assessment of cell viability. Among the tetrazolium compounds most commonly used is MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...
Ludmil Benov
doaj   +1 more source

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

Advanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi Gu   +4 more
wiley   +1 more source

Detecting viable but non-culturable lactic acid bacteria following spray-drying and during storage

The European Chemistry and Biotechnology Journal
Microencapsulation with various materials has been used as an efficient method to improve the viability of probiotic bacteria in multiple food products and the human gastrointestinal tract.
Meriam Bouri, Sibel Simsek Yazici, Fikrettin Sahin   +2 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

In Vitro Activity of Citrus IntegroPectin Against Breast Cancer and Colon Cancer

ChemFoodChem, EarlyView.
Image shows microscopic photographs of MCF‐7 cells in the presence of lemon, red orange, and sweet orange IntegroPectin bioconjugates at 0.5 or 1.0 mg/mL concentration after 24 h next to a photograph of MCF‐7 cells as such (control). ABSTRACT We investigate the ability of IntegroPectin bioconjugates obtained via acoustic cavitation of lemon, red orange,
Claudia D'Anna, Caterina Di Sano, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna, Mario Pagliaro   +5 more
wiley   +1 more source

Fluorescent redox-dependent labeling of lipid droplets in cultured cells by reduced phenazine methosulfate

Heliyon, 2020
Natural and synthetic phenazines are widely used in biomedical sciences. In dehydrogenase histochemistry, phenazine methosulfate (PMS) is applied as a redox reagent for coupling reduced coenzymes to the reduction of tetrazolium salts into colored ...
Juan C. Stockert, María C. Carou, Adriana G. Casas, María C. García Vior, Sergio D. Ezquerra Riega, María M. Blanco, Jesús Espada, Alfonso Blázquez-Castro, Richard W. Horobin, Daniel M. Lombardo   +9 more
doaj   +1 more source