Results 61 to 70 of about 24,486 (253)
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Heterocyclic Communications, 2019 Novel congeners of naphthalene substituted benzo[c]coumarins (2a-f) were synthesized by reaction of various 3-coumarinoyl methyl pyridinium bromide salts (1a-d) with a selected set of acetyl naphthalene in the presence of sodium acetate in refluxing ...
Patel Mrugesh, Patel Kaushal
doaj +1 more source
Scientific Reports, 2021 A major number of studies have demonstrated Beta-tricalcium phosphate (β-TCP) biocompatibility, bioactivity, and osteoconductivity characteristics in bone regeneration.
Cheuk Sing Choy +8 more
doaj +1 more source
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
Ternary ion-association complexes of cobalt with 4-(2-pyridylazo)resorcinol and tetrazolium salts
Acta Chimica Slovenica, 2014 The formation of ternary ion-association complexes of Co(II) with 4-(2-pyridylazo)resorcinol (PAR) and tetrazolium salts (TS) – (3-(4,5-dimethylThiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and 3-(2-naphtyl)-2,5-diphenyl-2H-tetrazolium chloride
Vanya Dimitrova Lekova +4 more
doaj
, 2016 We report on the synthesis, characterization, stability and pharmacokinetics of novel iron based contrast agents for magnetic resonance imaging (MRI). Statistical copolymers combining multiple phosphonic acid groups and poly(ethylene glycol) (PEG) were ...
Berret, J. -F. +6 more
core +4 more sources
Anticancer activity of rutin and its combination with ionic liquids on renal cells [PDF]
, 2020 The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC.
Araújo, Maria Eduarda Machado +6 more
core +1 more source
Advanced Science, EarlyView.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim +6 more
wiley +1 more source
Effect of growth media on the MTT colorimetric assay in bacteria.
PLoS ONE, 2019 Reduction of tetrazolium salts to colored formazan products by metabolically active cells is widely used for assessment of cell viability. Among the tetrazolium compounds most commonly used is MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...
Ludmil Benov
doaj +1 more source
In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]
, 2014 Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core +2 more sources