Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes
Glia, Volume 74, Issue 9, September 2026.Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani +5 more
wiley +1 more source
An improved competitive inhibition enzymatic immunoassay method for tetrodotoxin quantification
Biological Procedures Online, 2012 Quantifying tetrodotoxin (TTX) has been a challenge in both ecological and medical research due to the cost, time and training required of most quantification techniques.
Stokes Amber N +2 more
doaj +1 more source
Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors
Glia, Volume 74, Issue 8, August 2026.In early brain development, neuronal activity reduces OPC differentiation. Decreased neuronal activity changes oligodendrocyte gene expression, including upregulating glutamate receptor genes. AMPA signaling regulates the final stages of OPC differentiation.
Tessa E. Allen +4 more
wiley +1 more source
Molecular Basis of Voltage-Gated Sodium Channel Interaction with Marine Toxins Tetrodotoxin (TTX) from the Puffer Fish, Tetraodontidae [PDF]
, 2022 Shaoying Wu
openalex +1 more source
Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity‐Dependent in Adult Rats
Glia, Volume 74, Issue 8, August 2026.In adulthood, astrocytic mGluR5 increases synaptic efficacy through presynaptic A2ARs. This occurs when a small number of synapses are activated simultaneously. This pathway is abolished when numerous synapses are recruited. ABSTRACT Data accumulated over the last two decades have demonstrated that astrocytes play key roles in the regulation of ...
Sarah Mountadem +18 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4939-4952, August 2026.Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi +13 more
wiley +1 more source
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current
Marine Drugs, 2011 Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved.
Jaakko Haverinen +2 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira +3 more
wiley +1 more source
Tetrodotoxins (TTXs) and Vibrio alginolyticus in Mussels from Central Adriatic Sea (Italy): Are They Closely Related? [PDF]
, 2021 Simone Bacchiocchi +10 more
openalex +1 more source
Spatial variability and depuration of tetrodotoxin in the bivalve Paphies australis from New Zealand
Toxicon: X, 2019 Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications globally. Despite its potency and widespread occurrence in taxonomically diverse species, the primary source of TTX remains uncertain.
Laura Biessy +5 more
doaj +1 more source