Results 141 to 150 of about 16,950 (172)

Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons

Brain Research Bulletin, 2000
Ketamine, a general anesthetic, has been reported to block sodium channels. Two types of Na(+) channels, tetrodotoxin (TTX)-sensitive (TTX-s) and TTX-resistant (TTX-r), are expressed in dorsal root ganglion (DRG) neurons. The present study was to investigate the effects of ketamine on both types, particularly on TTX-r channels, using whole-cell patch ...
Z Q Zhao, Zhi-Qi Zhao
exaly   +3 more sources

LC-MS/MS method for the determination of tetrodotoxin (TTX) on a triple quadruple mass spectrometer

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2016
Tetrodotoxin (TTX), often referred to as the 'puffer fish' poison, is a marine toxin and it has been identified as the agent responsible for many food poisoning incidents around the world. It is a neurotoxin that blocks voltage-gated sodium channels, resulting in respiratory paralysis and even death in severe cases.
Ambrose Furey, Mary Lehane
exaly   +3 more sources

Quantitative detection of tetrodotoxin (TTX) by a surface plasmon resonance (SPR) sensor

Sensors and Actuators B: Chemical, 2008
Abstract We report the quantitative antibody-based detection of a low-molecular weight molecule tetrodotoxin (TTX) (∼319 Da) by inhibition assay with a surface plasmon resonance (SPR) sensor. A novel anti-TTX antibody sensing surface was developed by chemically immobilizing TTX on a gold film with a mixed self assembled monolayer (SAM) consisting of ...
Shaoyi Jiang, Sherwood Hall
exaly   +2 more sources

Acute cardiovascular, antiarrhythmic and toxic effects of tetrodotoxin (TTX) in unanesthetized dogs

Toxicology and Applied Pharmacology, 1972
Abstract Five unanesthetized dogs were given iv doses of 0.3, 0.6, 1.2, 2.4 and 4.8 μg/kg of TTX infused over 5 min periods at 65 min intervals. In similar experiments 4 anesthetized dogs were given serial doses of saline. Emesis occurred in 3 or 4 dogs after each dose of TTX, and the highest dose produced respiratory arrest and death in 4 of the 5 ...
B R, Duce, H S, Feldman, E R, Smith
openaire   +2 more sources

Detection of tetrodotoxin (TTX) from two copepods infecting the grass puffer Takifugu niphobles: TTX attracting the parasites?

Toxicon, 2006
In May 2002, two parasitic copepods, Pseudocaligus fugu and Taeniacanthus sp., were collected from the body surface and gill of the grass puffer Takifugu niphobles, respectively, in Takehara city, Hiroshima Prefecture, faced with Seto Inland Sea located in the western part of Japan.
Susumu Ohtsuka, Shigeto Taniyama, Yasuo Shida   +2 more
exaly   +3 more sources

Intracellular visualization of tetrodotoxin (TTX) in the skin of a puffer Tetraodon nigroviridis by immunoenzymatic technique

Toxicon, 2003
Micro-distributions of tetrodotoxin (TTX) in the skin of a brackish-water puffer Tetraodon nigroviridis were investigated by means of a monoclonal anti-TTX antibody under light and transmission electron microscope. In light microscopy TTX antigen was visualized as brown color in undifferentiated basal cells and succiform cells of the skin, while in ...
Yahia, Mahmud, Osamu, Arakawa, Akitoyo, Ichinose, Mohosena, Begum Tanu, Tomohiro, Takatani, Kazumi, Tsuruda, Kentaro, Kawatsu, Yonekazu, Hamano, Tamao, Noguchi   +8 more
openaire   +2 more sources

Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ Channels

The Journal of Pharmacology and Experimental Therapeutics, 2007
The excitability of sensory neurons depends on the expression of various voltage-gated Na+ channel isoforms. The tetrodotoxin-resistant (TTXr) Na+ channel Na(v)1.8 accounts for the electroresponsiveness of nociceptive neurons and contributes to inflammatory and neuropathic pain.
Andreas, Leffler, Anne, Reiprich, Durga P, Mohapatra, Carla, Nau   +3 more
openaire   +2 more sources

Mechanism of Action of Tetrodotoxin (TTX) and Saxitoxin (STX)

1971
Marine toxins such as TTX and STX have aroused the interest of physiologists, biochemists, pharmacologists, and biological warfare people, as well as writers of spy and mystery stories. In the hands of the neuroscientist they have been turned into helpful instruments vital for the study of nerve function and excitable membranes.
openaire   +1 more source

Effect of tetrodotoxin (TTX) on some brain neurotransmitters in rats.

Journal of natural toxins, 2002
Tetrodotoxin (TTX) is a potent marine neurotoxin named after the order of fish from which it is most commonly associated, the Tetraodontiforms, or the tetraodon pufferfish. In the present study the crude TTX was extracted from pufferfish Lagocephalus sceleratus collected from the Red Sea in Egypt.
Z A, Zaki, E A, Mady, S M, Ahmed, N M, Youssef   +3 more
openaire   +1 more source

Evaluation of the genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2007
The genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) was evaluated in a battery of in vitro and in vivo genotoxicity assays. These comprised a bacterial reverse-mutation assay (Ames test), an in vitro human lymphocyte chromosome-aberration assay, an in vivo mouse bone-marrow micronucleus assay and an in vivo rat-liver UDS assay. Maximum
Antonio, Guzmán, Antonio R, Fernández de Henestrosa, Ana-Paz, Marín, Ahn, Ho, Jorge I González, Borroto, Inés, Carasa, Lincoln, Pritchard   +6 more
exaly   +3 more sources