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Antinociceptive effects of tetrodotoxin (TTX) in rodents [PDF]
British Journal of Anaesthesia, 2006 Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models.Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice were used in the writhing test.
J, Marcil +5 more
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Toxicon, 2014
Tetrodotoxin (TTX) is a small molecular weight neurotoxin that occludes voltage-gated sodium channels in nerve and muscle tissue, resulting in respiratory paralysis and death. A high affinity antibody that can neutralize the toxicity of TTX is still lacking, so it is very important to prepare an antibody for TTX therapy and detection.
Shihua Wang, Rongzhi Wang
exaly +3 more sources
Tetrodotoxin (TTX) is a small molecular weight neurotoxin that occludes voltage-gated sodium channels in nerve and muscle tissue, resulting in respiratory paralysis and death. A high affinity antibody that can neutralize the toxicity of TTX is still lacking, so it is very important to prepare an antibody for TTX therapy and detection.
Shihua Wang, Rongzhi Wang
exaly +3 more sources
SERS Study of Tetrodotoxin (TTX) by Using Silver Nanoparticle Arrays
Plasmonics, 2009The optical properties of tetrodotoxin (TTX), a scarce toxin with anesthetic properties, were studied using nanoparticle arrays-assisted surface-enhanced Raman scattering (SERS). The nanoparticles arrays were fabricated using nanosphere lithography and a metallic lift-off process to control the particle size, shape, and spacing in the arrays.
Deng-Fwu Hwang +2 more
exaly +2 more sources
Toxicon, 2021
Adults of the ectoparasitic copepod Caligus fugu found on tetrodotoxin (TTX)-bearing pufferfish such as Takifugu alboplumbeus and Takifugu flavipterus are known to accumulate TTX in body tissues and parts other than the ovaries, oviducts, eggs, and cuticles.
Susumu Ohtsuka, Osamu Arakawa
exaly +3 more sources
Adults of the ectoparasitic copepod Caligus fugu found on tetrodotoxin (TTX)-bearing pufferfish such as Takifugu alboplumbeus and Takifugu flavipterus are known to accumulate TTX in body tissues and parts other than the ovaries, oviducts, eggs, and cuticles.
Susumu Ohtsuka, Osamu Arakawa
exaly +3 more sources
A Global Retrospective Study on Human Cases of Tetrodotoxin (TTX) Poisoning after Seafood Consumption [PDF]
Food Reviews International, 2020 The presented global retrospective study on human cases of tetrodotoxin (TTX) intoxication caused by seafood consumption was aimed at updating the relative risk according to seafood product categories (fish, gastropods, cephalopods, arthropods) and ...
Valentina Meucci +2 more
exaly +2 more sources
Brain Research Bulletin, 2000
Ketamine, a general anesthetic, has been reported to block sodium channels. Two types of Na(+) channels, tetrodotoxin (TTX)-sensitive (TTX-s) and TTX-resistant (TTX-r), are expressed in dorsal root ganglion (DRG) neurons. The present study was to investigate the effects of ketamine on both types, particularly on TTX-r channels, using whole-cell patch ...
Z Q Zhao, Zhi-Qi Zhao
exaly +3 more sources
Ketamine, a general anesthetic, has been reported to block sodium channels. Two types of Na(+) channels, tetrodotoxin (TTX)-sensitive (TTX-s) and TTX-resistant (TTX-r), are expressed in dorsal root ganglion (DRG) neurons. The present study was to investigate the effects of ketamine on both types, particularly on TTX-r channels, using whole-cell patch ...
Z Q Zhao, Zhi-Qi Zhao
exaly +3 more sources
Seafood cross-contamination by tetrodotoxin (TTX): management of an unusual route of exposure
Journal of Consumer Protection and Food Safety, 2023In this study, liquid chromatography with tandem mass spectroscopy was applied to detect Tetrodotoxin and analogues (TTXs) on pufferfish (Sphoeroides marmoratus) tissues, accidentally found in the stomach of a cuttlefish (Sepia officinalis). The cuttlefish tissues were also analysed.
Tinacci L. +5 more
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Quantitative detection of tetrodotoxin (TTX) by a surface plasmon resonance (SPR) sensor
Sensors and Actuators B: Chemical, 2008Abstract We report the quantitative antibody-based detection of a low-molecular weight molecule tetrodotoxin (TTX) (∼319 Da) by inhibition assay with a surface plasmon resonance (SPR) sensor. A novel anti-TTX antibody sensing surface was developed by chemically immobilizing TTX on a gold film with a mixed self assembled monolayer (SAM) consisting of ...
Shaoyi Jiang, Sherwood Hall, Jon Ladd
exaly +2 more sources
THE SCENT OF DANGER: TETRODOTOXIN (TTX) AS AN OLFACTORY CUE OF PREDATION RISK
Ecological Monographs, 2006Larvae of the California newt (Taricha torosa) exhibit striking predator-avoidance behavior, escaping to refuges in response to a chemical cue from cannibalistic adults. In laboratory flow-tank experiments, stream water collected near free-ranging adults induced hiding responses in 100% of the larvae tested.
Patrick Krug, Lee B Kats, Ryan P Ferrer
exaly +2 more sources
Toxicon, 2015
High concentrations of the neurotoxin tetrodotoxin (TTX) were detected by liquid chromatography-mass spectrometry (LC-MS) in the Platyhelminthes Stylochoplana sp. from Pilot Bay (Tauranga, New Zealand). This is the first detection of TTX in this genus. Concentrations were monitored from March to November (2013) and found to significantly decrease from ...
Lauren Salvitti +4 more
openaire +2 more sources
High concentrations of the neurotoxin tetrodotoxin (TTX) were detected by liquid chromatography-mass spectrometry (LC-MS) in the Platyhelminthes Stylochoplana sp. from Pilot Bay (Tauranga, New Zealand). This is the first detection of TTX in this genus. Concentrations were monitored from March to November (2013) and found to significantly decrease from ...
Lauren Salvitti +4 more
openaire +2 more sources