Results 91 to 100 of about 28,419 (196)

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 23, Page 6767-6786, December 2026.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Concentrations of Tetrodotoxin (TTX) and Its Analogue 4,9-Anhydro TTX in Different Tissues of the Silver-Cheeked Pufferfish (Lagocephalus sceleratus, Gmelin, 1789) Caught in the South-Eastern Mediterranean Sea, Lebanon. [PDF]

Toxins (Basel), 2022
Hassoun AER, Ujević I, Jemaa S, Roje-Busatto R, Mahfouz C, Fakhri M, Nazlić N.   +6 more
europepmc   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

The effect of enteral obestatin administration on the electrical field stimulation (EFS)—Evoked amplitude of contraction [mm] in the presence or absence of Tetrodotoxin (TTX (10⁻⁶ M)) in duodenal and middle jejunum strips from piglets.

, 2020
The effect of enteral obestatin administration on the electrical field stimulation (EFS)—Evoked amplitude of contraction [mm] in the presence or absence of Tetrodotoxin (TTX (10−6 M)) in duodenal and middle jejunum strips from piglets.
Żaneta Dzięgelewska (8611431), Maria Boryczka (8611425), Jarosław Woliński (4097539), Monika Słupecka-Ziemilska (5873888), Piotr Wychowański (8611428), Paulina Szczurek (4097545), Małgorzata Gajewska (468127), Atsukazu Kuwahara (5873897), Ikuo Kato (295418)   +8 more
core   +1 more source

Tetrodotoxin-resistant sodium channels in neuropathic pain

, 2000
Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury.
Jenny Fjell Hjelmström (19527955)
core   +1 more source

Stable Tetrodotoxin Production by Bacillus sp. Strain 1839

, 2019
For the first time, tetrodotoxin (TTX) was detected in a bacterial strain after five years of cultivation in laboratory conditions since its isolation from the animal host.
Anna E. Vlasenko, Daria I. Melnikova, Timur Yu. Magarlamov   +2 more
core   +1 more source

Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes

, 2017
Tetrodotoxin (TTX) is an extremely toxic marine neurotoxin. TTX inhibits voltage-gated sodium channels, resulting in a potentially lethal inhibition of neurotransmission.
Sub IRAS Tox CMT/NTX, dIRAS RA-1, Westerink, Remco H S, Emma E.J. Kasteel, Remco H.S. Westerink, LS IRAS Tox CMT/ATX, Kasteel, Emma E J   +6 more
core   +1 more source

Functional Constraints and the Evolution of TTX-resistance in TTX-bearing Salamanders [PDF]

, 2013
Tetrodotoxin (TTX) binds to voltage-gated sodium (NaV) channels, blocking the initiation of action potentials and the activity of nerve and muscle fibers. Some salamanders use TTX as an anti-predator defense.
Haslem, Angela
core   +1 more source

Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier   +4 more
doaj   +1 more source