Investigating Diet as the Source of Tetrodotoxin in Pleurobranchaea maculata [PDF]
Marine Drugs, 2013 The origin of tetrodotoxin (TTX) is highly debated; researchers have postulated either an endogenous or exogenous source with the host accumulating TTX symbiotically or via food chain transmission.
Serena Khor +6 more
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No Evidence for a Culturable Bacterial Tetrodotoxin Producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida) [PDF]
Toxins, 2015 Tetrodotoxin (TTX) is a potent neurotoxin found in the tissues of many taxonomically diverse organisms. Its origin has been the topic of much debate, with suggestions including endogenous production, acquisition through diet, and symbiotic bacterial ...
Lauren R. Salvitti +3 more
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The toxic mechanism and application of tetrodotoxin (TTX) [PDF]
MATEC Web of ConferencesTetrodotoxin (TTX) is a powerful toxin related to nerve cells that is commonly discovered at loads of puffer fish, and working out the best way of cooking, whereas keeping the flavour but getting rid of the toxicity has challenged people for decades, which removing the organ with toxin is currently most certified.
Zhang Xiaonan, Xiaonan Zhang
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Tissue accumulation of tetrodotoxin (TTX) and analogues in trumpet shell Charonia lampas
Food Additives & Contaminants: Part A, 2022 Tetrodotoxin (TTX) is a potent neurotoxin responsible for a human intoxication event in Spain associated with the consumption of trumpet shell Charonia lampas. In Europe, TTX is not regulated or monitored, and there is little knowledge about its presence in seafood.
Lage, Sandra +4 more
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Identifying environmental factors associated with tetrodotoxin contamination in bivalve mollusks using eXplainable AI [PDF]
npj Science of FoodSince 2012, tetrodotoxin (TTX) has been found in seafoods such as bivalve mollusks in temperate European waters. TTX contamination leads to food safety risks and economic losses, making early prediction of TTX contamination vital to the food industry and
M. C. Schoppema +6 more
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Human Foetal Neuroblasts Exhibit BK Channel-Dependent Membrane Voltage Oscillations upon Depolarization. [PDF]
Adv Sci (Weinh)Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Coppi E +9 more
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Repurposing of thermally stable nucleic-acid aptamers for targeting tetrodotoxin (TTX). [PDF]
Comput Struct Biotechnol J, 2022 Tetrodotoxin (TTX) is a lethal neurotoxin produced by the endosymbiotic bacteria in the gut of puffer fish. Currently, there is no effective and economical method to detect TTX, so it is very interesting to develop low-cost and high-sensitivity detection methods by using nucleic-acid aptamers as the recognition molecules.
Li Y +5 more
europepmc +4 more sources
Cholecystokinin Induces Ca<sup>2+</sup> Transients in Brainstem Neurons, Astrocytes and Central Vagal Terminals in Jugular/Nodose Ganglia-Brainstem Slice Cultures. [PDF]
Eur J NeurosciA jugular/nodose ganglion–brainstem slice culture with intact ganglia attached to the brainstem, preserving functional vagal afferent pathways to the brainstem. In this preparation, cholecystokinin activates brainstem neurons, central vagal terminals and brainstem astrocytes, establishing this preparation as a powerful model for dissecting the neuro ...
Ujhelyi A, Kucharz RS, Rekling JC.
europepmc +2 more sources
Marine Drugs, 2023 Gymnodimine D (GYM D), 16-desmethyl gymnodimine D (16-desmethyl GYM D), and two tetrodotoxin analogues have been found in invertebrates obtained from the north Atlantic coast of Spain from May 2021 to October 2022.
Araceli E. Rossignoli +3 more
doaj +1 more source
Confirmation and distribution of tetrodotoxin for the first time in terrestrial invertebrates: two terrestrial flatworm species (Bipalium adventitium and Bipalium kewense). [PDF]
PLoS ONE, 2014 The potent neurotoxin tetrodotoxin (TTX) is known from a diverse array of taxa, but is unknown in terrestrial invertebrates. Tetrodotoxin is a low molecular weight compound that acts by blocking voltage-gated sodium channels, inducing paralysis. However,
Amber N Stokes +7 more
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