Results 81 to 90 of about 10,876 (160)
Toxic mechanism and detection methods of tetrodotoxin [PDF]
MATEC Web of ConferencesTetrodotoxin (TTX) was first isolated in the early 20th century and has significant public health implications, especially in areas where puffer fish are consumed, such as Japan.
Xu Yunzhe
doaj +1 more source
Toxins, 2020 Some nemertean species from the genus Cephalothrix accumulate tetrodotoxin (TTX) in extremely high concentrations. The current study is the first to provide high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) data on tetrodotoxin
Anna E. Vlasenko, Timur Yu. Magarlamov
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The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis
International Endodontic Journal, EarlyView.ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson +3 more
wiley +1 more source
Recent research progress in tetrodotoxin detection and quantitative analysis methods
Frontiers in ChemistryTetrodotoxin (TTX) is a highly potent and widely distributed ion-channel marine neurotoxin; it has no specific antidote and poses a great risk to human health.
Chao Lin +10 more
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, 2019 (a) Profile of secretion of salivary fluid in response to pilocarpine treatment in the presence or absence of tetrodotoxin (TTX) in submandibular glands of rats. Submandibular glands were stimulated with 10 μM pilocarpine in the absence of TTX.
Takanori Narita (25602) +3 more
core +1 more source
Identification of TREK channels in mouse intracardiac ganglion neurons
The Journal of Physiology, EarlyView.Abstract figure legend Role of TWIK‐related K+ (TREK) channels in intracardiac ganglion neurons. CD‐1 mice were used to establish primary cultures of intracardiac neurons for immunochemical characterization and patch‐clamp electrophysiology. Intracardiac neurons express functional TREK channels, which modulate neuronal excitability by regulating ...
Ana Campos‐Rios +9 more
wiley +1 more source
Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing
The Journal of Physiology, EarlyView.Abstract figure legend Nociceptive C‐fibres display activity‐dependent slowing (ADS) whereby successive action potentials are conducted progressively slower thus regulating the temporal relay of pain signals. This study shows that the ADS induced by short stimulus trains (which mimic stimulus evoked firing, shown in orange) is modified by prior ...
Atanaska N. Velichkova, Carole Torsney
wiley +1 more source
The Journal of Clinical InvestigationMultiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
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Seasonal Changes in the Tetrodotoxin Content of the Flatworm Planocera multitentaculata
Marine Drugs, 2017 Tetrodotoxin (TTX) is a potent neurotoxin that acts specifically on voltage-gated sodium channels on excitable membranes of muscle and nerve tissues. The biosynthetic process for TTX is unclear, although marine bacteria are generally thought to be the ...
Riko Yamada +12 more
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Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source