Results 31 to 40 of about 26,735 (204)
A Progress on the Application of Tetrodotoxin [PDF]
E3S Web of Conferences, 2021 Tetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, and originated in endosymbiont-vibrio. Researches have confirmed that TTX affected the action potential through the regulation of voltage-gated sodium ...
Wang Zhaojia, Zhou Zhenning
doaj +1 more source
The First Data on the Complete Genome of a Tetrodotoxin-Producing Bacterium
Toxins, 2021 Tetrodotoxin (TTX)-producing bacteria have attracted great interest as a model system for study of the TTX biosynthetic route. Here, we report the complete genome of the TTX-producing bacterium Bacillus sp. 1839.
Daria I. Melnikova +2 more
doaj +1 more source
Total Synthesis of Tetrodotoxin and 9-epiTetrodotoxin [PDF]
, 2023 Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and an-algesic effects. Here, we present a scalable asymmetric synthesis of TTX and 9-epiTTX from the abundant chemical feed-stock furfuryl ...
Yuze, Sun +9 more
core +2 more sources
Genetic basis for tetrodotoxin (TTX) resistance in Nassarius [PDF]
, 2020 Understanding the genetic basis in animals possessing toxin could provide us significant insights into the adaptive evolution in toxin resistance. The reason of toxin resistance may refer to the mutation in sodium channels or the toxin-binding proteins.
Shanmei Zou, Yuxiao Hua
openaire +1 more source
Paralytic shellfish toxins (PSTs) and tetrodotoxin (TTX) of Korean pufferfish
Fisheries and Aquatic Sciences, 2021 Paralytic shellfish toxins (PSTs) and tetrodotoxin (TTX) are neurotoxins that display pharmacological activity that is similar to that of specific sodium channel blockers; they are the principle toxins involved in shellfish and puffer fish poisoning. In Korea, puffer fish is a very popular seafood, and several cases of accidental poisoning by TTX have ...
Ka Jeong Lee +6 more
openaire +3 more sources
An Overview of the Anatomical Distribution of Tetrodotoxin in Animals
Toxins, 2022 Tetrodotoxin (TTX), a potent paralytic sodium channel blocker, is an intriguing marine toxin. Widely distributed in nature, TTX has attracted attention in various scientific fields, from biomedical studies to environmental safety concerns. Despite a long
Daria I. Melnikova, Timur Yu. Magarlamov
doaj +1 more source
Toxins, 2021 Nemertea is a phylum of marine worms whose members bear various toxins, including tetrodotoxin (TTX) and its analogues. Despite the more than 30 years of studying TTXs in nemerteans, many questions regarding their functions and the mechanisms ensuring ...
Anna E. Vlasenko +6 more
doaj +1 more source
An Updated Review of Tetrodotoxin and Its Peculiarities
Marine Drugs, 2022 Tetrodotoxin (TTX) is a crystalline, weakly basic, colorless organic substance and is one of the most potent marine toxins known. Although TTX was first isolated from pufferfish, it has been found in numerous other marine organisms and a few terrestrial ...
Panagiota Katikou +4 more
doaj +1 more source
Marine Drugs, 2011 Puffer fish, Takifugu niphobles, collected from the Hong Kong coastal waters were screened for tetrodotoxin-producing bacteria. A Gram-negative, non-acid-fast, non-sporing and rod shaped bacterial strain (designated as gutB01) was isolated from the ...
Fred Wang-Fat Lee +3 more
doaj +1 more source
Structures of mu O-conotoxins from Conus marmoreus - Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons [PDF]
, 2004 The muO-conotoxins are an intriguing class of conotoxins targeting various voltage-dependent sodium channels and molluscan calcium channels. In the current study, we have shown MrVIA and MrVIB to be the first known peptidic inhibitors of the transient ...
Thomas, L. +27 more
core +1 more source