Results 101 to 110 of about 10,876 (160)

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes

, 2017
Tetrodotoxin (TTX) is an extremely toxic marine neurotoxin. TTX inhibits voltage-gated sodium channels, resulting in a potentially lethal inhibition of neurotransmission.
Sub IRAS Tox CMT/NTX, dIRAS RA-1, Westerink, Remco H S, Emma E.J. Kasteel, Remco H.S. Westerink, LS IRAS Tox CMT/ATX, Kasteel, Emma E J   +6 more
core   +1 more source

The effect of enteral obestatin administration on the electrical field stimulation (EFS)—Evoked amplitude of contraction [mm] in the presence or absence of Tetrodotoxin (TTX (10⁻⁶ M)) in duodenal and middle jejunum strips from piglets.

, 2020
The effect of enteral obestatin administration on the electrical field stimulation (EFS)—Evoked amplitude of contraction [mm] in the presence or absence of Tetrodotoxin (TTX (10−6 M)) in duodenal and middle jejunum strips from piglets.
Żaneta Dzięgelewska (8611431), Maria Boryczka (8611425), Jarosław Woliński (4097539), Monika Słupecka-Ziemilska (5873888), Piotr Wychowański (8611428), Paulina Szczurek (4097545), Małgorzata Gajewska (468127), Atsukazu Kuwahara (5873897), Ikuo Kato (295418)   +8 more
core   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Stable Tetrodotoxin Production by Bacillus sp. Strain 1839

, 2019
For the first time, tetrodotoxin (TTX) was detected in a bacterial strain after five years of cultivation in laboratory conditions since its isolation from the animal host.
Anna E. Vlasenko, Daria I. Melnikova, Timur Yu. Magarlamov   +2 more
core   +1 more source

Detection of Food Contaminants Based on Dual‐Mode Electrochemical and Optical Aptasensors: A Review

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Combining electrochemical (amperometry/impedance) and optical (colorimetry, fluorescence, SERS) readouts, this aptasensor offers complementary signal verification for reliable, sensitive food contaminant detection. Nanostructures and nucleic acid circuits amplify signals.
Yulin Meng, Chao Han, Haoyu Zhai, Xueli Zhang, Haibin Liu, Hongshuo Chen   +5 more
wiley   +1 more source

Downregulation of Tetrodotoxin-Resistant Sodium Currents and Upregulation of a Rapidly Repriming Tetrodotoxin-Sensitive Sodium Current in Small Spinal Sensory Neurons after Nerve Injury

, 1997
Clinical and experimental studies have shown that spinal sensory neurons become hyperexcitable after axonal injury, and electrophysiological changes have suggested that this may be attributable to changes in sodium current expression.
Theodore R. Cummins, Stephen G. Waxman
core   +1 more source

Impaired Motor Function in a Zebrafish Stathmin‐2 Knockout Model

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Stathmin‐2 (STMN2) is a microtubule‐associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.
Tyler J. N. Gurberg, Ziyaan A. Harji, Christian J. Rampal, Joséphine Sacy‐Richer, Amy Wang, Esteban C. Rodríguez, Gary A. B. Armstrong   +6 more
wiley   +1 more source