Results 171 to 180 of about 17,066 (197)

Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ Channels

The Journal of Pharmacology and Experimental Therapeutics, 2007
The excitability of sensory neurons depends on the expression of various voltage-gated Na+ channel isoforms. The tetrodotoxin-resistant (TTXr) Na+ channel Na(v)1.8 accounts for the electroresponsiveness of nociceptive neurons and contributes to inflammatory and neuropathic pain.
Andreas, Leffler, Anne, Reiprich, Durga P, Mohapatra, Carla, Nau   +3 more
openaire   +2 more sources

Mechanism of Action of Tetrodotoxin (TTX) and Saxitoxin (STX)

1971
Marine toxins such as TTX and STX have aroused the interest of physiologists, biochemists, pharmacologists, and biological warfare people, as well as writers of spy and mystery stories. In the hands of the neuroscientist they have been turned into helpful instruments vital for the study of nerve function and excitable membranes.
openaire   +1 more source

Effect of tetrodotoxin (TTX) on some brain neurotransmitters in rats.

Journal of natural toxins, 2002
Tetrodotoxin (TTX) is a potent marine neurotoxin named after the order of fish from which it is most commonly associated, the Tetraodontiforms, or the tetraodon pufferfish. In the present study the crude TTX was extracted from pufferfish Lagocephalus sceleratus collected from the Red Sea in Egypt.
Z A, Zaki, E A, Mady, S M, Ahmed, N M, Youssef   +3 more
openaire   +1 more source

Evaluation of the genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2007
The genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) was evaluated in a battery of in vitro and in vivo genotoxicity assays. These comprised a bacterial reverse-mutation assay (Ames test), an in vitro human lymphocyte chromosome-aberration assay, an in vivo mouse bone-marrow micronucleus assay and an in vivo rat-liver UDS assay. Maximum
Antonio, Guzmán, Antonio R, Fernández de Henestrosa, Ana-Paz, Marín, Ahn, Ho, Jorge I González, Borroto, Inés, Carasa, Lincoln, Pritchard   +6 more
exaly   +3 more sources

Source, ecological function, toxicity and resistance of Tetrodotoxin (TTX) in TTX-bearing organisms: a comprehensive review

Toxin Reviews, 2023
Ying Zhang, Shanmei Zou, Shaowu Yin, Tao Wang   +3 more
openaire   +1 more source

Asymmetric Fos labeling in lobule X of the cerebellum following transtympanic tetrodotoxin (TTX) in the rat

Neuroscience Letters, 2003
Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the granular and molecular layers of ...
openaire   +2 more sources

Transcriptomic analysis reveals the genes involved in tetrodotoxin (TTX) accumulation, translocation, and detoxification in the pufferfish Takifugu rubripes

Chemosphere, 2022
, Jilun Hou, Hanyuan Zhang
exaly  

11-Oxo tetrodotoxin and a specifically labelled 3H-TTX

Toxicon, 1996
B.Q. Wu, C.Y. Kao, M. Yotsu, T. Yasumoto, S.R. Levinson   +4 more
openaire   +1 more source

TTX (Tetrodotoxin)

Cold Spring Harbor Protocols, 2010
openaire   +1 more source

Tetrodotoxin (TTX) Stock Solution

Cold Spring Harbor Protocols, 2014
openaire   +1 more source