Results 31 to 40 of about 16,938 (165)

Tetrodotoxins Secretion and Voltage-Gated Sodium Channel Adaptation in the Ribbon Worm Kulikovia alborostrata (Takakura, 1898) (Nemertea)

Toxins, 2021
Nemertea is a phylum of marine worms whose members bear various toxins, including tetrodotoxin (TTX) and its analogues. Despite the more than 30 years of studying TTXs in nemerteans, many questions regarding their functions and the mechanisms ensuring ...
Anna E. Vlasenko, Vasiliy G. Kuznetsov, Grigorii V. Malykin, Alexandra O. Pereverzeva, Peter V. Velansky, Konstantin V. Yakovlev, Timur Yu. Magarlamov   +6 more
doaj   +1 more source

Tetrodotoxin Concentrations in Pleurobranchaea maculata: Temporal, Spatial and Individual Variability from New Zealand Populations

Marine Drugs, 2012
Tetrodotoxin (TTX) is a potent neurotoxin that has been identified in a range of phylogenetically unrelated marine and terrestrial organisms. Tetrodotoxin was recently detected in New Zealand in Pleurobranchaea maculata (the grey side-gilled sea slug ...
Stephen Craig Cary, Susanna A. Wood, Janet Adamson, Paul McNabb, Jarrod Walker, David I. Taylor   +5 more
doaj   +1 more source

Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals

Marine Drugs, 2013
Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported.
Brett A. Neilan, Susanna A. Wood, John A. Kalaitzis, Rocky Chau   +3 more
doaj   +1 more source

Isolation and Identification of a New Tetrodotoxin-Producing Bacterial Species, Raoultella terrigena, from Hong Kong Marine Puffer Fish Takifugu niphobles

Marine Drugs, 2011
Puffer fish, Takifugu niphobles, collected from the Hong Kong coastal waters were screened for tetrodotoxin-producing bacteria. A Gram-negative, non-acid-fast, non-sporing and rod shaped bacterial strain (designated as gutB01) was isolated from the ...
Fred Wang-Fat Lee, Peter Hoi-Fu Yu, Vincent Chung-Him Yu, Kin-Chung Ho   +3 more
doaj   +1 more source

An Updated Review of Tetrodotoxin and Its Peculiarities

Marine Drugs, 2022
Tetrodotoxin (TTX) is a crystalline, weakly basic, colorless organic substance and is one of the most potent marine toxins known. Although TTX was first isolated from pufferfish, it has been found in numerous other marine organisms and a few terrestrial ...
Panagiota Katikou, Cengiz Gokbulut, Ali Rıza Kosker, Mònica Campàs, Fatih Ozogul   +4 more
doaj   +1 more source

Investigating Diet as the Source of Tetrodotoxin in Pleurobranchaea maculata

Marine Drugs, 2013
The origin of tetrodotoxin (TTX) is highly debated; researchers have postulated either an endogenous or exogenous source with the host accumulating TTX symbiotically or via food chain transmission.
Serena Khor, Susanna A. Wood, Lauren Salvitti, David I. Taylor, Janet Adamson, Paul McNabb, Stephen Craig Cary   +6 more
doaj   +1 more source

Tissue accumulation of tetrodotoxin (TTX) and analogues in trumpet shell Charonia lampas

Food Additives & Contaminants: Part A, 2022
Tetrodotoxin (TTX) is a potent neurotoxin responsible for a human intoxication event in Spain associated with the consumption of trumpet shell Charonia lampas. In Europe, TTX is not regulated or monitored, and there is little knowledge about its presence in seafood.
Lage, Sandra, Afonso, Inês I., Reis Costa, Pedro, Canário, Adelino V. M., Da Silva, José P.   +4 more
openaire   +4 more sources

Prostaglandin E2 Has No Effect on Two Components of Tetrodotoxin-Resistant Na+ Current in Mouse Dorsal Root Ganglion

Journal of Pharmacological Sciences, 2007
One possible mechanism underlying inflammation-induced sensitization of the primary afferent neuron is the upregulation of tetrodotoxin-resistant (TTX-R) Na+ current by inflammatory mediators such as prostaglandins.
Taixing Zheng, Jun-ichi Kakimura, Tomoya Matsutomi, Chizumi Nakamoto, Nobukuni Ogata   +4 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Toxins, 2020
Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX
Mojgan Kavoosi, Terry E. O’Reilly, Mehran Kavoosi, Peng Chai, Caroline Engel, Walter Korz, Christopher C. Gallen, Robert M. Lester   +7 more
doaj   +1 more source

Does Ocean Sunfish Mola spp. (Tetraodontiformes: Molidae) Represent a Risk for Tetrodotoxin Poisoning in the Portuguese Coast?

Marine Drugs, 2022
Tetrodotoxin (TTX) is a potent neurotoxin naturally occurring in terrestrial and marine organisms such as pufferfish. Due to the risk of TTX poisoning, fish of Tetraodontidae family and other puffer-related species must not be placed in the EU markets ...
Miguel Baptista, Ana Catarina Braga, Rui Rosa, Pedro Reis Costa   +3 more
doaj   +1 more source