Results 81 to 90 of about 17,174 (147)

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

GABAergic TH2 Amacrine Cells Participate in Spontaneous Wave Activity in the Developing Retina

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
Individual TH2 amacrine cells (TH2‐ACs) exhibited spontaneous rhythmic depolarizations during the first and second postnatal weeks, driven by cholinergic starburst amacrine cells (SACs) and glutamatergic bipolar cells (BCs), respectively. Calcium imaging further revealed that these spontaneous depolarizations propagate across the TH2‐AC network in a ...
Wenqiu Wang, Heather E. Durfee, Yasmeen Hassan, Stephanie M. Bumbaru, Anthony J. Barbu, Alycen Wiacek, Dao‐Qi Zhang   +6 more
wiley   +1 more source

Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier   +4 more
doaj   +1 more source

Synaptobrevin‐2 Containing Extracellular Vesicles Are Rapidly Incorporated Into Mammalian Neurons via a Dynamin‐Dependent Pathway

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
In this article, Hannett and colleagues investigate extracellular vesicles (EVs) secreted by neurons, small membrane‐bound organelles that transmit information among cells. They found that EVs are mainly uptaken by target neurons via a mechanism dependent on the membrane scission protein Dynamin.
Victoria Hannett, A. Alejandro Vilcaes, Siewert Hugelier, Qing Tang, Melike Lakadamyali, Natali L. Chanaday   +5 more
wiley   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Electrostatic tuning of NaV channel activation by the domain II S3–S4 extracellular loop

The Journal of Physiology, Volume 604, Issue 17, Page 7210-7224, 1 September 2026.
Abstract figure legend Voltage‐gated sodium (NaV) channels are critical for electrical signalling, yet the molecular determinants that tune isoform‐specific activation remain incompletely understood. Here, we show that charged amino acids in the extracellular DII S3–S4 loop of NaV1.7 play a key role in setting voltage‐dependent activation.
Ashvriya Thapa, Lotten Ragnarsson, Hue Tran, Angelo Keramidas, Jennifer R. Deuis, Irina Vetter   +5 more
wiley   +1 more source

Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment

Marine Drugs
Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms.
Xinxin Zhang, Kun Qiao, Ruimin Cui, Min Xu, Shuilin Cai, Qilin Huang, Zhiyu Liu   +6 more
doaj   +1 more source

Oestrogen modulates stress‐induced vagally‐dependent gastric responses to oxytocin

The Journal of Physiology, Volume 604, Issue 18, Page 7570-7593, 15 September 2026.
Abstract figure legend In female rats, PVNCRF‐DMV neurons and DMV CRF1 receptors are tonically active, allowing oxytocin (OXT) to modulate inhibitory GABAergic transmission to DMV neurons. Parasympathetic control of gastric functions involves engagement of non‐adrenergic non‐cholinergic vagal efferent pathways, but recruitment of distinct pathways ...
Ruchi Bhagat, R. Alberto Travagli, Kirsteen N. Browning   +2 more
wiley   +1 more source

The Potential Mechanisms of Althaea rosea (Linn.) Cavan. Flower in Alleviating Tetrodotoxin Poisoning: An Integrated Metabolomics, Network Pharmacology and Experimental Validation

Drug Design, Development and Therapy
Renjin Zheng,1,2 Youjia Wu,1 Lingyi Huang,1 Fanxiang Zeng,3 Liying Huang1 1School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, 350122, People’s Republic of China; 2Physical and Chemical Analysis Department, Fujian Center for Disease Control ...
Zheng R, Wu Y, Huang L, Zeng F, Huang L
doaj  

Tetrodotoxin (TTX) reshapes the functional potential of the gut microbiome in juvenile tiger pufferfish (Takifugu rubripes) across salinity gradients. [PDF]

Anim Microbiome
Wassel MA, Makabe-Kobayashi Y, Iqbal MM, Huang C, Amano M, Shimizu A, Mandario MAE, Takatani T, Sakakura Y, Hamasaki K.   +9 more
europepmc   +1 more source