Results 111 to 120 of about 27,160 (211)
Advanced Science, Volume 13, Issue 52, 18 September 2026.This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 54, 28 September 2026.LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan +29 more
wiley +1 more source
Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes
Glia, Volume 74, Issue 9, September 2026.Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani +5 more
wiley +1 more source
Acute toxicity of tetrodotoxin (TTX). Should tetrodotoxin be part of the PSP class of toxins?
, 2019 Tetrodotoxin recognized as an emerging risk by international regulators Issues with TTX from pufferfish are well-known throughout history. TTX more recently identified in bivalve molluscs: -- Japan (scallops) -- NZ (pipi) -- UK (mussels and oysters ...
Sarah Finch (15395276)
core
A Stereoselective Synthesis of (−)-Tetrodotoxin
, 2016 An asymmetric synthesis of the fugu fish poison, (−)-tetrodotoxin, is described. The route to this extraordinary target employs a number of unique transformations, foremost of which are two stereospecific C−H bond functionalization reactions. Accordingly,
Andrew Hinman (2993631) +1 more
core +1 more source
Tetrodotoxin (TTX) is an extremely potent paralytic toxin responsible for yearly illness and death around the world. A clinical measurement is necessary to confirm exposure because symptoms of TTX intoxication cannot be distinguished from other paralytic
core
Purification and Characterization of Tetrodotoxin-binding Substance in Shore Crab Hemolymph [PDF]
, 2001 P(論文)テトロドトキシン(TTX)は古くからフグ毒の主成分として知られる。1964年にカリフォルニアイモリの毒がTTXに同定されて以来,これまでに微生物から両生類にいたる多種の生物に存在することが明らかにされてきた。TTXは神経細胞のNaチャンネルを選択的にブロックして,神経の興奮を阻害する作用を持つ神経毒であるとされている。TTXを保有しない一般の硬骨魚類のTTXの腹腔内投与に対する抵抗性はマウスと同程度の体重20g当たり約1MUである。これに対して ...
楠田, 理一 +9 more
core
Studies on Toxin-Producing Ability and Gene Map of Tetrodotoxin- Producing Bacteria
, 2010 [[abstract]]Tetrodotoxin (TTX) is one of the best known marine toxins, because of it’s an extremely potent, low-molecular weight, and non-protein neurotoxin. TTX exists with its several analogs.
Chun lan, Lin
core
Study of reproductive activity, maturity stages and tetrodotoxin (TTX) in yellow pufferfish, xenopterus naritus [PDF]
, 2016 This study was carried out in order to document the reproductive activity, maturity stages and tetrodotoxin (TTX) distribution in yellow pufferfish, Xenopterus naritus from Batang Saribas, Sarawak.
Herman Hermawan, Bakr i
core
1. Toxification of pufferfish and transfer of tetrodotoxin (TTX) among TTX-bearing organisms
NIPPON SUISAN GAKKAISHI, 2022 openaire +1 more source