Results 31 to 40 of about 391 (204)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Automatic Representative News Generation using On-Line Clustering
Emitter: International Journal of Engineering Technology, 2013 The increasing number of online news provider has produced large volume of news every day. The large volume can bring drawback in consuming information efficiently because some news contain similar contents but they have different titles that may appear.
Marlisa Sigita +3 more
doaj +3 more sources
Benchmarking of Document Image Analysis Tasks for Palm Leaf Manuscripts from Southeast Asia
Journal of Imaging, 2018 This paper presents a comprehensive test of the principal tasks in document image analysis (DIA), starting with binarization, text line segmentation, and isolated character/glyph recognition, and continuing on to word recognition and transliteration for ...
Made Windu Antara Kesiman +8 more
doaj +1 more source
BMJ Open, 2023 Objective This scoping review identifies evidence for design, models and evaluation of integrated care service provision for families and children in the first 2000 days, in the context of community-based specialised health, education and welfare ...
Sharyn Burns +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Working with batches of PDF files
The Programming Historian, 2020 Learn how to perform OCR and text extraction with free command line tools like Tesseract and Poppler and how to get an overview of large numbers of PDF documents using topic modeling.
Moritz Mähr
doaj
A novel local skew correction and segmentation approach for printed multilingual Indian documents
Alexandria Engineering Journal, 2018 Till date, many Indian government organizations do not have robust software to search for words from scanned office documents having complex multilingual Indian scripts. Manual search of such a multilingual Indian document will take few minutes and there
Narasimha Reddy Soora +1 more
doaj +1 more source
Deep Sparse Auto-Encoder Features Learning for Arabic Text Recognition
IEEE Access, 2021 One of the most recent challenging issues of pattern recognition and artificial intelligence is Arabic text recognition. This research topic is still a pervasive and unaddressed research field, because of several factors.
Najoua Rahal +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source