Results 51 to 60 of about 786,568 (316)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Филологический класс, 2019 The article analyzes the monograph “Texts – Images – Communicates” by Jana Sokolova. The monograph combines the methods of linguocognitology, Gestalt psychology and discourse analysis to solve the problem of a combination of a text, an image and a ...
doaj +1 more source
The enemies within: Gog of Magog in Ezekiel 38–39
HTS Teologiese Studies/Theological Studies, 2017 The most extensive descriptions of Gog and Magog in the Hebrew Bible appear in Ezekiel 38–39. At various stages of their political career, both Reagan and Bush have linked Gog and Magog to the bêtes noires of the USA, identifying them either as the ...
Lydia Lee
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Irish Texts Society 2014 [PDF]
, 2014 This pamphlet includes objects, subscription, officers and council, list of ...
Irish Texts Society +1 more
core
A Sociolinguistic Study of Conversations in Chinua Achebe’s A Man of the People [PDF]
Journal of Humanistic and Social Studies, 2017 This paper examines sociolinguistic features of conversational interactions among characters in Achebe’s A Man of the People. The aim is to differ from the largely stylistic examination of the text, and therefore, to study conversations in the ...
Kazeem K. Olaniyan
doaj
Discursive Semantics: Ontological Foundations and the Experience of Reconstruction
Филологический класс, 2022 The article considers the issue of essential features and ways of describing the semantics of discourse understood as an array of texts, which is formed by the value-based (ideological in a broad sense) position of the speaking subject.
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
lascivaroma/additional-texts 1.0.151
, 2021 Additional texts that were easy to convert and that would benefit ...
Thibault Clérice
core +1 more source