Results 61 to 70 of about 67,034 (219)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Vivenciando a outridade: escalas, indexicalidade e performances narrativas de universitários migrantes

Revista Brasileira de Linguística Aplicada, 2018
RESUMO Considerando a mobilidade dos signos e dos textos, o objetivo do artigo é analisar as performances narrativas construídas por três alunos de graduação que migraram para estudar.
Letícia Fonseca Richthofen de Freitas, Luiz Paulo da Moita Lopes   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cacophony: Ways to Preserve the Complexity of Subjects in the Research Presentation

Forum: Qualitative Social Research, 2009
The main objective of this paper is to present and argue for the relevance of a non-linear, interactive presentation of results of a qualitative investigation of language attitudes.
Jacob Thögersen
doaj  

TRANSFER OF CATEGORIES AND TERMINOLOGY BETWEEN ‘TEXT’ AND ‘TEXTS’. AN INTERDISCIPLINARY MODEL OF THE CONCEPT ‘TEXT’ AND IT’S HISTORY FROM TEXT CRITICISM TO CONTEMPORARY DISCOURSE IN ARTS AND SCIENCES [PDF]

Diversitate si Identitate Culturala in Europa, 2016
This article is interested in the phenomenon ʻtext‘ both as a cognitive and linguistic concept and as a construct in the history of scholarship with a historical review of definitions and functions of the text as well as studies of concrete texts. In the
Fee-Alexandra HAASE
doaj  

Investigating Adolescent Critical Literacy Engagement

Language and Literacy: A Canadian Educational e-journal, 2015
In this paper the author considers adolescents’ important texts and how they are adopting a critical literacy approach towards them. Qualitative data are presented that demonstrate how critically minded these adolescents are when engaging with texts. The
Sarah Elizabeth Bonsor Kurki
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

One or more? Big or small? Number and size of animate characters in picture books from Japan and the U.S.

Psychology of Language and Communication
We examined the number and size of animate characters illustrated in picture books targeting preschoolers from the U.S. and Japan. Our hypotheses were based on cross-cultural differences found in previous studies of visual attention and visual products ...
Kuwabara Megumi, Perez Bonnie
doaj   +1 more source