Results 91 to 100 of about 3,235 (226)

Biologic Therapies: Targeting Severe Asthma at the Molecular Level

Journal of Education, Health and Sport
Introduction: Severe asthma is a chronic respiratory condition that affects a significant number of individuals, causing persistent inflammation of the airways and leading to recurrent symptoms such as wheezing, coughing, and shortness of breath ...
Kamila Szewczyk, Bartłomiej Szewczyk, Wiktoria Julia Krzesłowska, Paulina Pytel, Szymon Wiśniewski, Weronika Hołownia   +5 more
doaj   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, Volume 81, Issue 9, Page 3221-3235, September 2026.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Allergy, Volume 81, Issue 9, Page 3157-3170, September 2026.
ABSTRACT Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed airflow limitation, and long‐term morbidity, particularly in severe disease. Although biologic therapies have transformed outcomes by reducing exacerbations and systemic corticosteroid exposure, their potential to modify structural airway ...
Sebastiano Gangemi, Sara Manti, Johann Christian Virchow, Giorgio Walter Canonica   +3 more
wiley   +1 more source

Comparative Effectiveness of Tezepelumab and Dupilumab in Asthma: A Multinational Retrospective Cohort Study.

Journal of Allergy and Clinical Immunology: In Practice
BACKGROUND Although both dupilumab and tezepelumab are approved for severe asthma, real-world evidence comparing their effectiveness remains limited.
Chun-Tse Hung, Yu-Chien Hung, Cheng An, Chi-Won Suk   +3 more
semanticscholar   +1 more source

Update on Pediatric asthma management: Recent advances

Pediatric Allergy and Immunology, Volume 37, Issue 9, September 2026.
Pathophysiology of asthma: an opportunity for personalized targeted therapeutics. Abstract Asthma remains the commonest chronic pediatric respiratory disease and a major cause of childhood morbidity worldwide. Recent advances in pediatric asthma management shift the focus from symptom relief alone towards early control of airway inflammation ...
Nitin Dhochak, Polly F. M. Robinson, Sejal Saglani   +2 more
wiley   +1 more source

Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature

Respiratory Medicine Case Reports
A 38-year-old man with near fatal asthma requiring intubation and invasive mechanical ventilation (IMV) was transferred to our hospital. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated due to hypotension and mediastinal emphysema ...
M. Nakajima, Masashi Matsuyama, Yuki Yamazaki, Hiroya Sunabe, Yuta Takahashi, Keishun Boku, Takeshi Miura, Tomohiro Tamura, Yoshiaki Inoue, Nobuyuki Hizawa   +9 more
semanticscholar   +1 more source

Revisiting CD8+ T Cells in Allergy: The Emerging Role of Tc2 Cells

Scandinavian Journal of Immunology, Volume 104, Issue 3, September 2026.
Tc2 CD8+ T cells in Type 2 inflammation: induction, tissue adaptation, metabolic programming, and therapeutic implications. Both naïve CD8+ T cells and pre‐committed Tc1 CD8+ T cells can be directed towards a Tc2 phenotype, characterised by secretion of the Type 2 cytokines IL‐4, IL‐5, IL‐9 and IL‐13, which in turn drive eosinophil recruitment, goblet ...
Sabrina de Souza Ferreira, Christopher Andrew Tibbitt   +1 more
wiley   +1 more source

Functionality and Performance of an Accessorized Pre-Filled Syringe and an Autoinjector for At-Home Administration of Tezepelumab in Patients with Severe, Uncontrolled Asthma

Journal of Asthma and Allergy, 2021
Sady Alpizar,1 Ayman Megally,2 Claudia Chen,3 Abhi Raj,4 John Downie,5 Gene Colice2 1Clinical Research Trials of Florida, Inc., Tampa, FL, USA; 2Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD,
Alpizar S, Megally A, Chen C, Raj A, Downie J, Colice G   +5 more
doaj  

Tezepelumab improved chronic eosinophilic pneumonia in severe asthma patients with liver cirrhosis

Frontiers in Medicine
Systemic administration of corticosteroids is used in the treatment of chronic eosinophilic pneumonia (CEP). However, in patients with CEP as well as other comorbidities, the adverse effects of corticosteroids should be minimized as much as possible.
Mizuki Inaba, Yasuo Shimizu, Yasuo Shimizu, Yusuke Nakamura, Hiroaki Okutomi, Akihiro Takemasa, Akihiro Takemasa, Seiji Niho   +7 more
doaj   +1 more source

Adherence to Inhaled Corticosteroids and Clinical Outcomes Following a Year of Tezepelumab Therapy for Severe Asthma.

Journal of Allergy and Clinical Immunology: In Practice
BACKGROUND High-dose inhaled corticosteroid (ICS) are associated with adverse effects. Reductions in ICS use whilst treated with anti-IL5/5R therapies can lead to reduced clinical effectiveness in some patients.
G. D'ancona, Faizan Haris, Jessica Gates, N. Stewart-Kelcher, L. Green, J. Lam, M. Fernandes, L. Thomson, C. Roxas, Zijing Yang, J. Dhariwal, A. Nanzer, David J. Jackson   +12 more
semanticscholar   +1 more source