Results 71 to 80 of about 3,235 (226)

Comparative efficacy and safety of monoclonal antibodies biologic therapies for chronic rhinosinusitis with nasal polyps: A systematic review and network meta-analysis

American Journal of Otolaryngology
Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents a significant therapeutic challenge with high recurrence rates despite the current standard treatments.
Abdulhakeem Almutairi, Lina Yousef Aloraini, Bader Muzhier Alshahrani, Maan Omar Alzuhairi, Rabab Hussain Alzanadi, Khalid Fahad Alanazi, Yahya Ali Khubrani, Ahmed Y. Azzam   +7 more
doaj   +1 more source

A Real-world Study on Tezepelumab Effectiveness in Severe Asthma Focusing on Small Airway Dysfunction.

Respiratory Medicine
BACKGROUND Severe asthma (SA) is a complex condition often involving small airway dysfunction (SAD). Tezepelumab has demonstrated efficacy in clinical trials, but real-world evidence is scarce, and its impact on SAD remains unexplored.
F. Menzella, M. Cottini, C. Lombardi, G. Senna, R. Chan, Annamaria Bosi, Michela Bortoli, S. Tonin, Lorenzo Corsi, Andrea Rastelli, M. Marchi   +10 more
semanticscholar   +1 more source

Knowledge and practice regarding eosinophilic gastrointestinal disorders other than eosinophilic esophagitis among pediatric gastroenterologists of the Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

JPGN Reports, EarlyView.
Abstract Objective Evaluating clinical practices in the management of non‐esophageal eosinophilic gastrointestinal disorders (non‐EoE EGIDs) among pediatric gastroenterologists in Latin America. Methods A cross‐sectional descriptive study was conducted using a survey distributed via the REDCap platform.
Sofia Paz, Michelle Higuera Carrillo, Alonso Rafael Echavez Agudelo, Mário Cesar Vieira, Juan Pablo Riveros López, Natali González Rozó, Gustavo Javier Tagliaferro, Fabiola Sánchez Hernández, Catalina Ortiz Piedrahita, Wilson Daza Carreño, Ailim Margarita Carias Domínguez, José Fernando Vera Chamorro, Sabine Krüger Truppel, Maximiliano Fernández Rivas, César Augusto Moreno Serrano, Pablo Torres Córdova, Carlos Marcelo Timossi, Pablo Vásquez   +17 more
wiley   +1 more source

The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)

, 2022
RATIONALE AND OBJECTIVES: Thymic stromal lymphopoietin (TSLP), an epithelial upstream cytokine, initiates production of type-2 (T2) cytokines with eosinophilia and possibly airway hyperresponsiveness (AHR) in asthma.This study aimed to determine whether ...
Erjefält, Jonas,, Sverrild, Asger, Uller, Lena, Hansen, Susanne, Backer, Vibeke,, Clausson, Carl-Magnus,, Cerps, Samuel,, Porsbjerg, Celeste, Clausson, Carl-Magnus, Uller, Lena,, Sverrild, Asger,, Hansen, Susanne,, Hvidtfeldt, Morten,, Hvidtfeldt, Morten, Cozzolino, Olga, Erjefält, Jonas, Cozzolino, Olga,, Backer, Vibeke, Cerps, Samuel, Porsbjerg, Celeste,, Lund University.   +20 more
core   +1 more source

Clinical response and on-treatment clinical remission with tezepelumab in a broad population of patients with severe, uncontrolled asthma: results over 2 years from the NAVIGATOR and DESTINATION studies

European Respiratory Journal
Graphical abstract Tezepelumab treatment was associated with an increased likelihood of achieving a complete clinical response and on-treatment clinical remission versus placebo in patients with severe, uncontrolled asthma.
M. Wechsler, G. Brusselle, J. Virchow, A. Bourdin, K. Kostikas, J. Llanos, S. Roseti, C. S. Ambrose, G. Hunter, D. Jackson, Mario Castro, N. Lugogo, Ian D. Pavord, Neil Martin, C. Brightling   +14 more
semanticscholar   +1 more source

Generative AI and Clinicians Show Comparable Prognostic Reasoning From Clinical Narratives in Biologic‐Treated CRSwNP

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To compare the ability of large language models (LLMs) and otolaryngologists to identify prognostic signals from brief clinical vignettes in CRSwNP. Methods In this blinded study, 68 adults initiating biologic therapy for CRSwNP (≥ 36 months follow‐up) were represented by standardized vignettes derived from documentation immediately ...
Sholem Hack, Chase Kahn, Ainhoa Garcia‐Lliberos, Cristina Rodriguez‐Prado, Ameen Biadsee, Maxime Fieux, Mark Liu, Eran Glikson, Masayoshi Takashima, Omar G. Ahmed, Raj Sindwani, Dennis M. Tang, Christopher R. Roxbury   +12 more
wiley   +1 more source

Efficacy and Potential Positioning of Tezepelumab in the Treatment of Severe Asthma

Open Respiratory Archives, 2023
The excellent results for monoclonal antibodies in the treatment of severe uncontrolled asthma (SUCA) represent a milestone in current treatment of asthmatic disorders.
Vicente Plaza, Conxa Cañete, Christian Domingo, Carlos Martínez Rivera, Xavier Muñoz   +4 more
doaj   +1 more source

Real-world data on tezepelumab in patients with severe asthma in Germany.

Journal of Allergy and Clinical Immunology: In Practice
BACKGROUND Tezepelumab is a novel biologic blocking thymic stromal lymphopoetin (TSLP), approved for severe asthma irrespective of biomarker levels or phenotype.
L. Biener, C. Mümmler, C. Hinze, Hendrik Suhling, S. Korn, Christoph Fisser, Arne Biener, C. Pizarro, A. Lenoir, Caroline M. Hackl, D. Skowasch, K. Milger   +11 more
semanticscholar   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

The National Allergy Centre of Excellence–Addressing Australia's Allergy Burden

Clinical &Experimental Allergy, EarlyView.
Australia's high allergy burden prompted a national response, leading to the establishment of the National Allergy Centre of Excellence (NACE) in 2022. The NACE has advanced research infrastructure, collaboration, and consumer‐centred care through four pillars, achieving global recognition and accelerating translation into policy, practice, and ...
A. Young, J. J. Koplin, D. E. Campbell, J. M. Davies, H. Edmund, T. Jamieson, C. J. Hornung, T. O'Farrell, D. West, E. Kayes, L. A. Gray, R. L. Peters, L. Gamble, K. Gwynne, J. Lee, M. Lucas, C. H. Katelaris, M. D. O'Sullivan, D. J. Palmer, J. Trubiano, S. van Nunen, S. L. Vale, T. Wanandy, K. P. Perrett   +23 more
wiley   +1 more source