Results 61 to 70 of about 2,407 (209)

Achieve Sustainability by Easing Population to 4 Billion by 2200

Sustainable Development, EarlyView.
ABSTRACT The past century of massive increases in human population and resource use has seen many undesirable environmental effects, ranging from biodiversity loss to climate change. But a research gap exists, as the ultimate causes are often not described with precision or mentioned at all.
Mark Keegan, Anastasia Pseiridis, Philip Cafaro, Jane O'Sullivan, William Rees, Estelle Monique Sidze, Lawrence Whitmore, Enrique J. Derlindati, Mohammad Mainul Islam, Khaoula Houssini, S. Irudaya Rajan   +10 more
wiley   +1 more source

Spatial and Temporal Regulation of Receptor Endocytosis in Neuronal Dendrites Revealed by Imaging of Single Vesicle Formation

Cell Reports, 2017
Endocytosis in neuronal dendrites is known to play a critical role in synaptic transmission and plasticity such as long-term depression (LTD). However, the inability to detect endocytosis directly in living neurons has hampered studies of its dynamics ...
Morgane Rosendale, Damien Jullié, Daniel Choquet, David Perrais   +3 more
doaj   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source

Reticulocyte transferrin receptor (TfR) expression and contribution to soluble TfR levels.

Haematologica, 2001
Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of these factors on reticulocyte TfR expression in vivo has never been studied. A soluble form of TfR (sTfR) is present in serum in proportion to the mass of cellular TfR. Although
R'Zik, Samir, Loo, Martine, Beguin, Yves
openaire   +2 more sources

Mapping diversity through geographical, environmental and attribute spaces

Methods in Ecology and Evolution, EarlyView.
Abstract Understanding biodiversity patterns requires integrating information across the interrelated dimensions that organize life. Species occupy specific regions in geographic space, respond to environmental conditions and vary within attribute (or trait) spaces that are shaped by their ecological and evolutionary histories.
Bruno Vilela, Bruna M. Farina, Ricardo Dobrovolski, Sidney F. Gouveia, José Alexandre F. Diniz‐Filho, Thiago F. Rangel, Trevor S. Fristoe, Carlos Calderón del Cid, Marco Túlio Pacheco Coelho, Catherine H. Graham, Fabricio Villalobos   +10 more
wiley   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Investigation of Different CNN-Based Models for Improved Bird Sound Classification

IEEE Access, 2019
Automatic bird sound classification plays an important role in monitoring and further protecting biodiversity. Recent advances in acoustic sensor networks and deep learning techniques provide a novel way for continuously monitoring birds.
Jie Xie, Kai Hu, Mingying Zhu, Jinghu Yu, Qibing Zhu   +4 more
doaj   +1 more source