Results 31 to 40 of about 1,965 (160)
Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis
Animal Research and One Health, EarlyView.Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang +11 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes +10 more
wiley +1 more source
Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis
Interdisciplinary Medicine, EarlyView.Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar +18 more
wiley +1 more source
Achieve Sustainability by Easing Population to 4 Billion by 2200
Sustainable Development, EarlyView.ABSTRACT The past century of massive increases in human population and resource use has seen many undesirable environmental effects, ranging from biodiversity loss to climate change. But a research gap exists, as the ultimate causes are often not described with precision or mentioned at all.
Mark Keegan +10 more
wiley +1 more source
Muhasebe Bilim Dünyası Dergisi, 2021 TFRS 9 Finansal Araçlar Standardına göre işletmeler beklenen kredi zararlarını mevcut ve geleceğe yönelik makul ve desteklenebilir bilgilere dayanarak belirlemelidirler. Ancak Covid-19 salgının yaratmış olduğu belirsizlik özellikle finansal alt yapısı zayıf işletmelerin geleceğe yönelik tahminler yapmasını zorlaştırmaktadır.
openaire +2 more sources
Smart Molecules, EarlyView.AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin +10 more
wiley +1 more source
Finansal Araştırmalar ve Çalışmalar Dergisi, 2020 Bu çalışmada 2018 yılından itibaren uygulamaya konulan Türkiye Finansal Raporlama Standardı (TFRS 9) kredi sınıflandırması ve karşılıkları üzerindeki etkisi Türk bankacılık sektöründe faaliyet gösteren seçilmiş mevduat bankaları özelinde incelenmektedir.
openaire +3 more sources
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
Pamukkale University Journal of Social Sciences Institute, 2020 This study explores the effects of the new impairment model, in IFRS 9, on the financial statements of deposit banks issued in 2018. In this respect, the changes in the provisions of the expected credit losses in three stages of the impairment model were analyzed. Further the study investigates the changes in specific and general provisions required by
SAYGILI, Ebru +2 more
openaire +3 more sources
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source