Results 31 to 40 of about 5,802,216 (159)

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

The ImproveCareNow Registry: Prediction of different remission rates in pediatric ulcerative colitis

JPGN Reports, EarlyView.
Abstract Objectives Identifying predictors of clinical remission in pediatric ulcerative colitis (UC) will impact the therapeutic approach. We aimed to predict time to first (TFR), corticosteroid‐free (TCSFR, ≥3 months corticosteroid withdrawal), and sustained remission (TSR, ≥6 months).
Jonathan Van Hecke, Gigi Veereman, Koen Huysentruyt, Lucas Wauters, Jeremy Adler, Shehzad Saeed, Elisabeth De Greef, and the ImproveCareNow Pediatric IBD Learning Health System   +7 more
wiley   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Length of intergenic DNAs between TFRs and their divergent neighbors.

, 2012
(A) Each of the 250 TFRs having divergent neighbors in SCO, SGR, and SAV is represented as a dot with the value on y-axis indicating the length of the intergenic sequence between its own gene and divergent gene.
Leslie Cuthbertson (114147), Justin R. Nodwell (114148), Sang Kyun Ahn (114146)   +2 more
core   +1 more source

Konsolide finansal tablolar standardının (TFRS 10) incelenmesi [PDF]

, 2015
Tez (Yüksek Lisans) -- İstanbul Ticaret Üniversitesi -- Kaynakça var.Bu çalışmanın amacı, Uluslararası Finansal Raporlama Standartları 10 ve onun resmi tercümesi Türkiye Finansal Raporlama Standartları 10 - Konsolide Finansal Tablolar Standardını kontrol
Savaşkan, Demet Emine
core   +1 more source

Achieve Sustainability by Easing Population to 4 Billion by 2200

Sustainable Development, EarlyView.
ABSTRACT The past century of massive increases in human population and resource use has seen many undesirable environmental effects, ranging from biodiversity loss to climate change. But a research gap exists, as the ultimate causes are often not described with precision or mentioned at all.
Mark Keegan, Anastasia Pseiridis, Philip Cafaro, Jane O'Sullivan, William Rees, Estelle Monique Sidze, Lawrence Whitmore, Enrique J. Derlindati, Mohammad Mainul Islam, Khaoula Houssini, S. Irudaya Rajan   +10 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source

Türkiye’de bankacılık sektöründe kredilendirme sürecinde TFRS 9 uyarınca beklenen kredi zarar karşılığı ölçümü ve örnek bir uygulama

, 2019
Kamu Gözetimi Muhasebe ve Denetim Standartları Kurumu tarafından yürürlüğe konulmuş olan TFRS 9 Finansal Araçlar Standardı ile finansal varlık ve yükümlülüklerin sınıflandırılması ve ölçümü, değer düşüklüğü ve finansal riskten korunma muhasebesi ile ...
Özel, Emrah
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