Results 41 to 50 of about 1,965 (160)

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

TFRS 9 ve temerrüt olasılığı modellemesi

, 2019
Bu makalede, 01 Ocak 2018’de yürürlüğe giren Finansal Araçlar Raporlama Standardının bankacılığa etkisi temerrüt olasılığı bağlamında ele alınmıştır. Standart gereği, bankaların beklenen kredi zararı hesaplamasında kullanılmak üzere raporlama döneminden sonraki on iki ayda ve kredi ömrü boyunca müşteriler için temerrüt etme olasılıklarının hesaplanması
Turanlı, Münevver, Taşkın, Celil
openaire   +1 more source

FİNANSMAN ARACI OLARAK SUKUK: TFRS-9 KAPSAMINDA MUHASEBELEŞTİRME AÇISINDAN BİR İNCELEME

Muhasebe ve Denetime Bakış
Sukuk varlığa dayalı olarak ihraç edilen ve çeşitli türleri olan, genellikle elinde bulundurduğu fonu yatırıma dönüştürmeyi isteyen fakat faizden kaçınmak isteyen yatırımcılar ve kuruluşlar tarafından tercih edilen bir İslami finans enstrümanıdır. Sukuk ihracında yatırımcı sadece nakit akışı değil aynı zamanda ihraç edilen varlık üzerinde mülkiyet ...
openaire   +2 more sources

Fertility incentives in Canada: Period and cohort perspectives

Canadian Journal of Economics/Revue canadienne d'économique, EarlyView.
Abstract We study the fertility effects of the 1997 Quebec Family Policy using two complementary approaches: (i) a period‐based repeated cross‐sectional analysis that examines the impact on period fertility (i.e., fertility rates in a given calendar year, such as births per 1,000 women age 15 to 49), and (ii) a cohort‐based panel analysis that examines
Siha Lee, Sitian Liu
wiley   +1 more source

Rendering Synthetic Defects for Learning‐Based Industrial Inspection

Computer Graphics Forum, EarlyView.
Abstract Computer vision increasingly uses synthetic data from physically based rendering to supplement limited real‐world datasets. In industrial inspection, defect data is scarce and the rendering pipeline is explicitly controlled, and synthetic defect generation therefore becomes a dataset design problem.
Runzhou Mao, Hiroyuki Sakai, Christian Freude, Christoph Garth, Petra Gospodnetić, Juraj Fulir   +5 more
wiley   +1 more source

Adapting UK Clinical Practise in Chronic Myeloid Leukaemia in Chronic Phase to Contemporary Management Recommendations: The ADAPT 2.0 Survey

European Journal of Haematology, EarlyView.
ABSTRACT Objective Chronic myeloid leukaemia in chronic phase (CML‐CP) treatment recommendations have changed substantially in recent years. The ADAPT 2.0 survey aimed to provide an updated understanding of CML‐CP management in the UK. Methods This healthcare professional (HCP) survey, conducted between December 2023 and June 2024, assessed treatment ...
Dragana Milojkovic, Nicholas C. P. Cross, Ketul Desai, Kathryn Frewin, Mhairi Copland   +4 more
wiley   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source