Results 51 to 60 of about 1,967 (163)

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Additional file 9 of The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

, 2022
Additional file9. HIV-infection does not modulate DPP4 and FCRL3 expression.
Mahlobo, Bongiwe, Laher, Faatima, Smidt, Werner, Ogunshola, Funsho, Khaba, Trevor, Nkosi, Thandeka, Mbatha, Anele, Ngubane, Thandekile, Dong, Krista, Jajbhay, Ismail, Pansegrouw, Johan, Ndhlovu, Zaza M.   +11 more
openaire   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, Volume 7, Issue 2, Page 35-51, June 2026.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Kredi zararı modeli yerine TFRS 9 beklenen zarar modelinin bankalarda uygulanması

, 2021
Uluslararası Muhasebe Standartları Kurumu (IASB), finansal araçlar olarak nitelendirilen kalemlerin sınıflandırılması, kolay anlaşılabilir olması ve raporlanmasının geliştirilmesi için 2005 yılında başlattığı projeyle TMS 39 Finansal Araçlar; Muhasebeleştirme ve Ölçme standartının yerine TFRS 9 standardını oluşturmaya başlamıştır.
openaire   +1 more source

Asciminib Provides Better Efficacy and Favorable Safety and Tolerability Against Investigator‐Selected Tyrosine Kinase Inhibitors in East Asian Patients With Newly Diagnosed Chronic Myeloid Leukemia: Results From a Subgroup Analysis of the Pivotal ASC4FIRST Study

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT ASC4FIRST (ClinicalTrials.gov NCT04971226) is a pivotal phase 3 clinical trial comparing the efficacy and safety of asciminib vs. standard of care (SoC) tyrosine kinase inhibitors (TKIs) in newly diagnosed patients with chronic myeloid leukemia in chronic phase (CML‐CP).
Naoto Takahashi, Dong‐Wook Kim, Inho Kim, Xin Du, Sung‐Eun Lee, Yu Hu, Yoshikane Kikushige, Qian Jiang, Yi Wang, Suning Chen, Huanling Zhu, Tatsunori Goto, Akihiro Tomita, Michiko Ichii, Hirohisa Nakamae, Lei Liu, Beini Liu, Kamel Malek, Tong Zhu, Shengyuan Wu, Jianxiang Wang   +20 more
wiley   +1 more source

Homozygous TFR2 (c.2093_2096del) Mutation in an Asymptomatic Patient With Type 3 Hereditary Hemochromatosis, First Report From Saudi Arabia

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hereditary hemochromatosis (HH) is an inherited disorder of iron metabolism characterized by progressive iron accumulation in multiple organs. While most cases are associated with HFE mutations, non‐HFE variants such as mutations in the transferrin receptor‐2 (TFR2) gene represent rare causes of iron overload.
Omar M. Raslan, Dana S. Alamoudi
wiley   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

TFRS 9’a geçişin borsa İstanbul’da işlem gören bankaların hisse senedi fiyatlarına etkileri

, 2020
The aim of this study is to determine the effect of the transition to TFRS 9 for banks that have significant financial instruments in the statements of financial statement tables and the effect of the average share prices of the banks whose shares are traded in Borsa Istanbul. In this context, by using quarterly data between 2016-2018, the significance
Çetinoğlu, Tansel, Karaarslan, Serhan
openaire   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source