Results 101 to 110 of about 4,308 (211)

Phase 1 randomized pharmacokinetic and safety study of a 90‐day tenofovir vaginal ring in the United States

Journal of the International AIDS Society
Introduction Tenofovir‐based oral pre‐exposure prophylaxis is currently approved for HIV prevention; however, adherence in women has been low. A vaginal gel containing tenofovir (TFV) demonstrated partial protection to HIV but protection was not ...
Albert Y. Liu, Holly Gundacker, Barbra Richardson, Beatrice A. Chen, Craig Hoesley, Ariane van derStraten, Amanda Brown, May Beamer, Jennifer Robinson, Cindy E. Jacobson, Rachel Scheckter, Katherine Bunge, Jill Schwartz, Andrea Thurman, Jeanna M. Piper, Mark A. Marzinke, the MTN‐038 Protocol Team for the Microbicide Trials Network   +16 more
doaj   +1 more source

NP-ARVs alone and in combination with free TFV show potent antiviral activity.

, 2013
Tenofovir (TFV) alone and in combination with efavirenz (EFV) or saquinavir (SQV) was investigated in TZM-bl cells. Data represent mean values obtained from triplicate infections.
Emily Krogstad (116925), Thanyanan Chaowanachan (116931), Kim A. Woodrow (116937), Cameron Ball (116922)   +3 more
core   +1 more source

EEO-TFV: Escape-Explore Optimizer for Web-Scale Time-Series Forecasting and Vision Analysis

Proceedings of the ACM Web Conference 2026
Transformer-based foundation models have achieved remarkable progress in tasks such as time-series forecasting and image segmentation. However, they frequently suffer from error accumulation in multivariate long-sequence prediction and exhibit vulnerability to out-of-distribution samples in image-related tasks.
Hua Wang 0012, Jinghao Lu, Fan Zhang 0045   +2 more
openaire   +2 more sources

In vitro release of TFV and LNG from full two-segment IVR.

, 2014
In vitro release of (A) TFV and (B) LNG for 90 days from final TFV/LNG (20 mm) IVR prototypes using Tecophilic and Tecoflex polymers (HP-100A-60 TFV reservoir tube, EG-85A LNG reservoir core and EG-65D LNG reservoir RCM and end-caps).
Justin T. Clark (531069), Andrew K. Andreasen (531074), Joel S. Nebeker (531075), Meredith R. Clark (531070), Todd J. Johnson (531072), David R. Friend (531077), Patrick F. Kiser (531078), Eric M. Smith (531073), Namdev B. Shelke (531071), Judit Fabian (531076)   +9 more
core   +1 more source

Spaghetti plot of tenofovir (TFV) concentrations.

, 2014
Hair TFV concentrations for each subject are shown for each dosing period. Each line represents drug concentration data from one participant (at 2, 4, and 7 doses/week). The red line distinguishes between hair scalp concentrations for 2 vs. 7 doses/week.
Albert Y. Liu (207707), Peter L. Anderson (507421), Chengshi Jin (507422), Kristefer Stojanovski (507424), Monica Gandhi (507425), Qiyun Yang (503880), Robert Grant (74834), Peter Bacchetti (75155), Kathy Goggin (507423), Susan P. Buchbinder (116220), Ruth M. Greenblatt (235035), Yong Huang (15745)   +11 more
core   +1 more source

FTC-TP and TFV-DP concentrations in PBMCs.

, 2019
Data reflects the concentrations of FTC-TP (A) and TFV-DP (B) measured in PBMCs from 4 macaques treated with daily oral FTC/TAF.
Susan Ruone (7871372), Julian Jolly (7871378), James L. Weed (5391317), Michele B. Daly (7871369), Chuong Dinh (7871375), April M. Clayton (6506819), James Mitchell (70177), J. Gerardo García-Lerma (7871381), Angela Holder (255187)   +8 more
core   +1 more source

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

Retrovirology, 2009
Background We investigated the effects of mutations K65R and K65R plus M184V on enzymatic function and mechanisms of drug resistance in subtype C reverse transcriptase (RT).
Coutsinos Dimitrios, Ntemgwa Michel L, Martinez-Cajas Jorge L, Xu Hong-Tao, Frankel Fernando A, Brenner Bluma G, Wainberg Mark A   +6 more
doaj   +1 more source

Comparison of viral replication [P24 antigen production] in ectocervical biopsy tissue obtained from participants at baseline [visit 3] and post-treatment [visit 7] after use of placebo, TFV and TFV/LNG rings.

, 2018
Comparison of viral replication [P24 antigen production] in ectocervical biopsy tissue obtained from participants at baseline [visit 3] and post-treatment [visit 7] after use of placebo, TFV and TFV/LNG rings.
Mark A. Marzinke (734979), Raina Fichorova (3131937), Meredith R. Clark (531070), Frank Z. Stanczyk (501434), Susana N. Asin (762321), Charlene S. Dezzutti (299787), Andrea Ries Thurman (5465414), Christiane Rollenhagen (5465405), Vivian Brache (200187), Gustavo F. Doncel (339755), Patrick Kiser (5465417), Jill L. Schwartz (200175), Betsy C. Herold (118186), Debra Weiner (5465408), Sharon L. Hillier (346279), Timothy McCormick (203413), Neelima Chandra (5465411)   +16 more
core   +1 more source

Brief Report: Role of Sociobehavioral Factors in Subprotective TFV-DP Levels Among YMSM Enrolled in 2 PrEP Trials

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2019
Background: Young men who have sex with men (YMSM) experience disparities in HIV acquisition more than any other group. Daily oral pre-exposure prophylaxis (PrEP) with tenofovir/emtricitabine has been shown to effectively prevent HIV transmission in YMSM; however, recent studies suggest that young Black men who have sex with ...
Renata, Arrington-Sanders, Craig M, Wilson, Suzanne E, Perumean-Chaney, Amit, Patki, Sybil, Hosek   +4 more
openaire   +3 more sources

Moderately High Tenofovir Diphosphate in Dried Blood Spots Indicates Drug Resistance in Viremic Persons Living with HIV

Journal of the International Association of Providers of AIDS Care, 2019
Background: Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a strong predictor of viral suppression in persons living with HIV (PLWH). Its association with antiretroviral therapy (ART) resistance remains unknown. Methods: Blood was collected
Jenna Lynn Yager PharmD, Ryan Patrick Coyle BA, Stacey Summer Coleman BS, BSN, Lucas Ellison BS, Jia-Hua Zheng PhD, Lane Bushman BChem, Edward Michael Gardner MD, Mary Morrow MS, Samantha MaWhinney ScD, Peter L. Anderson PharmD, Jennifer Justice Kiser PharmD, PhD, Jose Ramon Castillo-Mancilla MD   +11 more
doaj   +1 more source