Results 101 to 110 of about 29,782 (188)

Saikosaponin A Inhibits Migration/Invasion and Triggers Cell‐Cycle Arrest and Autophagy‐Induced Cell Death in HCT116 Cells and In Vivo

open access: yesFood Frontiers, Volume 7, Issue 3, May 2026.
Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang   +7 more
wiley   +1 more source

Characteristics and functions of B and T regulatory cells [PDF]

open access: yes, 2019
Imunosni odgovor potaknut izlaganjem nekom antigenu jednako je bitan kao i supresija imunosnog odgovora. U imunosnoj reakciji kao i supresiji sudjeluju brojne stanice koje surađuju i komuniciraju kroz različite molekularne mehanizme.
Petrić, Marijana
core   +2 more sources

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal   +6 more
wiley   +1 more source

Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration

open access: yesThe Laryngoscope, Volume 136, Issue 5, Page 2220-2231, May 2026.
Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal   +7 more
wiley   +1 more source

Distinct profile of inflammatory and remodelling biomarkers in sputum of severe asthmatic patients with or without persistent airway obstruction

open access: yesWorld Allergy Organization Journal, 2019
Background: Both inflammatory and remodelling processes are associated with irreversible airway obstruction observed in severe asthma. Our aim was to characterize a group of severe asthmatic patients with or without persistent airway obstruction in ...
Silvana Cianchetti   +9 more
doaj   +1 more source

Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
In a rat model of DHEA/DHT‐induced PCOS and in granulosa cells (GCs), upregulated DNMT1, DNMT3A, and DNMT3B inhibit TXNIP degradation, leading to TXNIP accumulation, which drives ovarian fibrosis and tissue injury. ABSTRACT Hyperandrogenism and elevated thioredoxin‐interacting protein (TXNIP) are potential causes of infertility in women with polycystic
Yajing Weng   +12 more
wiley   +1 more source

Immunohistochemical demonstration of TGF-ß and decorin in paracoccidioidal granulomas

open access: yesBrazilian Journal of Medical and Biological Research, 2003
Different patterns of granulomas have been observed in 6- to 8-week-old mice after ip inoculation with 5 x 10(6) yeast cells of Paracoccidioides brasiliensis.
A.S. Nishikaku, E. Burger
doaj   +1 more source

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