A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology
JOR SPINE, Volume 9, Issue 2, June 2026.A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou +11 more
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2003 La esclerodermia lineal (EL) es una forma localizada de la enfermedad, caracterizada por la proliferación fibroblástica y los infiltrados linfocitarios perivasculares en la dermis.
José Félix Restrepo +3 more
doaj +1 more source
Administration of TGF-ß Inhibitor Mitigates Radiation-induced Fibrosis in a Mouse Model. [PDF]
Clin Orthop Relat Res, 2021 Gans I +4 more
europepmc +1 more source
Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells. [PDF]
, 2019 Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an ...
Budi, Erine H +4 more
core
Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source
Activin A backs-up TGF-ß to promote regulatory T cells. [PDF]
Oncoimmunology, 2021 De Martino M +2 more
europepmc +1 more source
Effect of transforming growth factor-ß1 (TGF-ß1) released from a scaffold on chondrogenesis in an osteochondral defect model in the rabbit [PDF]
, 2006 Articular cartilage repair might be stimulated by the controlled delivery of therapeutic factors. We tested the hypotheses whether TGF-ß1 can be released from a polymeric scaffold over a prolonged period of time in vitro and whether its transplantation ...
Bezemer, Jeroen M. +7 more
core +3 more sources
Regulated Cell Death in Idiopathic Pulmonary Fibrosis
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan +10 more
wiley +1 more source
Letter to the Editor: Administration of TGF-ß Inhibitor Mitigates Radiation-induced Fibrosis in a Mouse Model. [PDF]
Clin Orthop Relat Res, 2021 Zhu YP +6 more
europepmc +1 more source
Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]
, 2004 Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Annett Streu +24 more
core +1 more source