Results 201 to 210 of about 270,164 (307)

Artificial Intelligence-Enhanced Precision Medicine Reveals Prognostic Impact of TGF-Beta Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer Among Disproportionately Affected Populations. [PDF]

Int J Mol Sci
Diaz FC, Waldrup B, Carranza FG, Manjarrez S, Velazquez-Villarreal E.   +4 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Assessment of Cytokines TNF-alpha, IFN-gamma, TGF-beta-1, and IL-10 in Malaria Patients of the River Nile State , Sudan: A critical study of immune response. [PDF]

BMC Immunol
Hamad MNM, Albadrani GM, Ghazwani AA, Abdelmola A, Suliman RS, Mahjaf GM, Fahmy SA, Badi S, Yassin HM, Othman GA, Altaher TA, Noor SK.   +11 more
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Molecular Alterations in TP53, WNT, PI3K, TGF-Beta, and RTK/RAS Pathways in Gastric Cancer Among Ethnically Heterogeneous Cohorts. [PDF]

Cancers (Basel)
Monge C, Waldrup B, Carranza FG, Velazquez-Villarreal E.   +3 more
europepmc   +1 more source

Spatiotemporal Organization of PTK7 Diffusion on Cell Surface Facilitates Tumor Invasion and Migration

Advanced Science, EarlyView.
The spatiotemporal dynamics of protein kinase diffusion govern cellular signaling and functions. Although vital for active receptors, the role of pseudokinase dynamics is unclear. Here, we use single‐molecule tracking to link faster diffusion of pseudokinase PTK7 to increased tumor cell invasion and migration.
Yaohua Li, Tao Pan, Yu Wang, Sainan Guo, Daiquan Chen, Liu Liu, Liwei Wang, Yang Sun, Weihong Tan   +8 more
wiley   +1 more source

Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Ceará, northeastern Brazil. [PDF]

Mem Inst Oswaldo Cruz
Luiz RDSS, Campelo TA, Silva CS, Nogueira LL, Sancho SO, da Silva AKA, Frota CC, Carvalho-Costa FA.   +7 more
europepmc   +1 more source

TGF-beta dynamically controls epithelial identity in a 3D model of human epiblast

, 2023
Zorzan I, Carbognin E, Lauria A, Proserpio V, Benegnù D, Dalrio C, Arboit M, Paolucci I, Drusin A, Sledziowska M, Amadei G, Oliviero S, Martello G.   +12 more
europepmc   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity. [PDF]

Stem Cell Res Ther
Wu C, Xu H, Wu Z, Huang H, Ge Q, Xu J, Chen J, Wang P, Yuan W, Jin H, Tong P.   +10 more
europepmc   +1 more source