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TGF-beta: a master immune regulator
Expert Opinion on Therapeutic Targets, 2020Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune checkpoint pathways are co-opted in cancer to induce T cell tolerance, this review posits that TGF ...
Bryan Oronsky +2 more
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TGF-beta and osteoarthritis. [PDF]
Osteoarthritis and cartilage, 2007 Item does not contain ...
Blaney Davidson, E.N. +2 more
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TGF-betas and TGF-beta receptors in atherosclerosis.
Cytokine & growth factor reviews, 2000Based on diverse evidence in animals and humans, it has been hypothesized that atherosclerosis, and other injury-induced hyperplasias such as restenosis, may result from a failure in endogenous inhibitory systems that normally limit wound repair and induce regression of wound repair cells.
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The International Journal of Developmental Biology, 1995
The critical stage of palatal development is the fusion of apposing individual palatal shelves. Palatal shelves, from the day 13 murine embryo, cultured in vitro fuse normally in the absence of exogenous factors. Therefore, some endogenous factor(s) is responsible for the normal fusion process. Prevention of mature TGF-beta 3 activity during a specific
C L, Brunet, P M, Sharpe, M W, Ferguson
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The critical stage of palatal development is the fusion of apposing individual palatal shelves. Palatal shelves, from the day 13 murine embryo, cultured in vitro fuse normally in the absence of exogenous factors. Therefore, some endogenous factor(s) is responsible for the normal fusion process. Prevention of mature TGF-beta 3 activity during a specific
C L, Brunet, P M, Sharpe, M W, Ferguson
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The Roles of TGF-Beta and TGF-Beta Signaling Receptors in Breast Carcinogenesis.
1995Abstract : The overall goal of this research project is to explore the roles of TGF-l3 and components of its signaling pathways in the initiation, progression and metastasis of breast adenocarcinomas through an investigation of the disregulation of TGF-B signal transduction.
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The Prostate, 1997
Prostate cancer eventually becomes androgen-independent, suggesting that growth factors such as TGF beta 1-3 may potentially contribute to prostate neoplasia. The pattern and level of TGF beta 1-3 protein expression in normal and malignant human prostate are unknown.An immunohistochemical study was undertaken to analyze TGF beta 1, TGF beta 2, and TGF ...
K T, Perry, C T, Anthony, M S, Steiner
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Prostate cancer eventually becomes androgen-independent, suggesting that growth factors such as TGF beta 1-3 may potentially contribute to prostate neoplasia. The pattern and level of TGF beta 1-3 protein expression in normal and malignant human prostate are unknown.An immunohistochemical study was undertaken to analyze TGF beta 1, TGF beta 2, and TGF ...
K T, Perry, C T, Anthony, M S, Steiner
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Molecular reproduction and development, 1992
The nature and role of cell surface proteins that bind members of the TGF-beta family has been investigated. TGF-beta, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF-beta system, these receptors are implicated in the mediation of multiple responses.
J, Massagué +6 more
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The nature and role of cell surface proteins that bind members of the TGF-beta family has been investigated. TGF-beta, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF-beta system, these receptors are implicated in the mediation of multiple responses.
J, Massagué +6 more
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Microbes and infection, 2000
Transforming growth factor-beta (TGF-beta) isoforms are multifunctional cytokines that play a central role in wound healing and in tissue repair. TGF-beta is found in all tissues, but is particularly abundant in bone, lung, kidney and placental tissue. TGF-beta is produced by many but not all parenchymal cell types, and is also produced or released by ...
M H, Branton, J B, Kopp
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Transforming growth factor-beta (TGF-beta) isoforms are multifunctional cytokines that play a central role in wound healing and in tissue repair. TGF-beta is found in all tissues, but is particularly abundant in bone, lung, kidney and placental tissue. TGF-beta is produced by many but not all parenchymal cell types, and is also produced or released by ...
M H, Branton, J B, Kopp
openaire +1 more source