Results 251 to 260 of about 270,164 (307)
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Journal of cellular physiology, 2008
Transforming growth factor-beta (TGF-beta) responsiveness in cultured cells can be modulated by TGF-beta partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. The TbetaR-II/TbetaR-I binding ratio of TGF-beta on the cell surface has recently been found to be a signal that controls TGF-beta partitioning between these ...
Chun-Lin, Chen +2 more
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Transforming growth factor-beta (TGF-beta) responsiveness in cultured cells can be modulated by TGF-beta partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. The TbetaR-II/TbetaR-I binding ratio of TGF-beta on the cell surface has recently been found to be a signal that controls TGF-beta partitioning between these ...
Chun-Lin, Chen +2 more
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TGF-beta: a master immune regulator
Expert Opinion on Therapeutic Targets, 2020Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune checkpoint pathways are co-opted in cancer to induce T cell tolerance, this review posits that TGF ...
Bryan Oronsky, David J Sher
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TGF-beta signaling in cancer radiotherapy
Cytokine, 2021Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early stages of carcinogenesis, but it also plays tumor-promoting roles in established tumors. Additionally, it plays a critical role in cancer radiotherapy.
Juan, Wang +4 more
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Molecular reproduction and development, 1992
The nature and role of cell surface proteins that bind members of the TGF-beta family has been investigated. TGF-beta, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF-beta system, these receptors are implicated in the mediation of multiple responses.
J, Massagué +6 more
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The nature and role of cell surface proteins that bind members of the TGF-beta family has been investigated. TGF-beta, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF-beta system, these receptors are implicated in the mediation of multiple responses.
J, Massagué +6 more
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TGF Beta Inhibition for Cancer Therapy
Current Cancer Drug Targets, 2006The importance of perturbation in transforming growth factor beta (TGFbeta) signaling for the onset and progression of cancer is well established. Many tumors over express TGFbeta, and high circulating levels of TGFbeta1 in cancer patients are frequently associated with poor prognosis. TGFbeta has context-dependent biphasic action during tumorigenesis.
Elise F, Saunier, Rosemary J, Akhurst
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Osteoarthritis and cartilage, 2007
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Blaney Davidson, E.N. +2 more
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Blaney Davidson, E.N. +2 more
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TGF-beta Signaling in Cancer Treatment
Current Pharmaceutical Design, 2014The transforming growth factor-beta (TGF-β ) belongs to a superfamily of cytokines that act on protein kinase receptors at the plasma membrane to induce a plethora of biological signals that regulate cell growth and death, differentiation, immune response, angiogenesis and inflammation.
Isabel, Fabregat +3 more
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TGF‐Beta Signaling in Breast Cancer
Annals of the New York Academy of Sciences, 2006Abstract: The antiestrogen tamoxifen is one of the most successful drugs in the endocrine treatment of breast cancer and significantly reduces the risk of recurrence and death. Antiestrogens act by inhibiting the production of growth‐stimulatory factors as well as by activating peptides with growth‐inhibitory effects like transforming growth factor ...
Miriam B, Buck, Cornelius, Knabbe
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TGF-beta signalling in colon carcinogenesis
Cancer Letters, 2012Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-β)/Smad signalling pathway.
Pavlos, Lampropoulos +5 more
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TGF-betas and TGF-beta receptors in atherosclerosis.
Cytokine & growth factor reviews, 2000Based on diverse evidence in animals and humans, it has been hypothesized that atherosclerosis, and other injury-induced hyperplasias such as restenosis, may result from a failure in endogenous inhibitory systems that normally limit wound repair and induce regression of wound repair cells.
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