Tumor-associated EGFR over-expression specifically activates Stat3 and Smad7 resulting in desensitization of TGF-β signaling [PDF]
, 2008 Transforming Growth Factor-[beta] (TGF-[beta]) and Epidermal Growth Factor (EGF) signaling pathways are both independently implicated as key regulators in tumor formation and progression.
Bo Wang +3 more
core +1 more source
Increased IL-6 and TGF-beta(1) concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy [PDF]
, 2004 peer reviewedaudience: researcherPURPOSE: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the bronchoalveolar lavage (BAL)
Albert, Adelin +12 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Transforming growth factor-beta superfamily members in the pathogenesis of pulmonary arterial hypertension [PDF]
Scripta Medica, 2012 Pulmonary arterial hypertension (PAH) is a devastating and rapidly progressing disease that induces substantial pulmonary vascular remodeling. The pathologic changes especially in pulmonary microvasculature result in progressive increases in the mean ...
Jerkić Mirjana
doaj
Concurrent and distinct transcription and translation of transforming growth factor-beta type I and type II receptors in rodent embryogenesis [PDF]
, 1998 The transforming growth factor-betas (TGF-betas) are multifunctional regulatory polypeptides that play a crucial role in many cell processes and function through a set of cell surface protein receptors that includes TGF-beta type I (RI) and type II (RII).
Cuttitta, F. (Frank) +4 more
core
A mathematical model of the stoichiometric control of Smad complex formation in TGF-B signal transducion pathway [PDF]
, 2009 Cell fate in multicellular organism is regulated by the diffusible factor from surrounding cells in concentration-dependent manner. TGF-beta is a large protein family of the diffusible proteins secreted from a localized source.
Nakabayashi, J., Sasaki, A.
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes. [PDF]
, 1991 Glucocorticoids (GC) modulate immune function in a number of ways, including suppression of T cell proliferation and other IL-2-mediated T cell functions.
AyanlarBatuman, O. +3 more
core +1 more source
Inhibition of TGF-B signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages [PDF]
, 2013 Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-beta has a multi-functional role in tumor development including modulating the biological activity of both the tumor
Chen, Y +9 more
core +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source