Results 61 to 70 of about 1,017,685 (306)

Transforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway

Reproductive Biology and Endocrinology, 2009
Background Transforming growth factor-beta (TGF-beta) is known to exert multiple regulatory functions in the human placenta, including inhibition of estrodial production. We have previously reported that TGF-beta1 decreased aromatase mRNA levels in human
Fu Guodong, Zhou Hong, Yu Hui, Peng Chun
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response

, 2012
Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-?, influences interferon (IFN) production by primary
Green, Ben, David Sammut (137689), Gisli Jenkins (137696), Bedke Nicole, Jenkins Gisli, Stephen T Holgate, Donna E Davies, Howarth, Peter H., Nicole Bedke (137686), Sammut, David, Jenkins, Gisli, Amanda Tatler, Holgate, Stephen T., Sammut David, Ben Green, Patrick Dennison, Stephen T. Holgate (137701), Valia Kehagia, Dennison Patrick, Holgate Stephen T., David Sammut, Amanda Tatler (137698), Davies Donna E., Nicole Bedke, Donna E. Davies (137702), Bedke, Nicole, Peter H Howarth, Green Ben, Peter H. Howarth (137699), Patrick Dennison (137694), Davies, Donna E., Valia Kehagia (137692), Gisli Jenkins, Tatler, Amanda, Tatler Amanda, Howarth Peter H., Ben Green (137690), Dennison, Patrick, Kehagia, Valia, Kehagia Valia   +39 more
core   +1 more source

Angiotensin II and transforming growth factor β affect cardiovascular and renal disease in patients with type 2 diabetes mellitus: benefits of dpp-4 inhibitors treatment

Ожирение и метаболизм, 2019
BACKGROUND: Diabetes mellitus type 2 (T2DM) is associated with impaired glucose metabolism and peripheral insulin resistance, which is accompanied by an high risk of cardiovascular disease (CVD) and nephropathy.
Teona A. Shvangiradze, Irina Z. Bondarenko, Ekaterina A. Troshina, Marina V. Shestakova, Larisa V. Nikankina, Natalia S. Fedorova   +5 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

TGF-beta 1 mediates glucose-evoked up-regulation of connexin-43 cell-to-cell communication in HCD-cells

, 2009
Background/Aims: In the current study we examined if the multifunctional cytokine TGF-beta 1 mediated glucose-evoked increases in connexin-43(Cx43)-mediated intercellular communication in cells of the human collecting duct (HCD).
P. M. Ronco (17189413), Claire Hills (17159905), R. Bland (17189416), J. Bennett (7627925), Paul Squires (17167891)   +4 more
core   +5 more sources

Transforming growth factor: beta signaling is essential for limb regeneration in axolotls. [PDF]

PLoS ONE, 2007
Axolotls (urodele amphibians) have the unique ability, among vertebrates, to perfectly regenerate many parts of their body including limbs, tail, jaw and spinal cord following injury or amputation. The axolotl limb is the most widely used structure as an
Mathieu Lévesque, Samuel Gatien, Kenneth Finnson, Sophie Desmeules, Eric Villiard, Mireille Pilote, Anie Philip, Stéphane Roy   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. [PDF]

PLoS ONE, 2018
Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients.
Folashade Otegbeye, Evelyn Ojo, Stephen Moreton, Nathan Mackowski, Dean A Lee, Marcos de Lima, David N Wald   +6 more
doaj   +1 more source