Results 51 to 60 of about 12,455 (120)

The Non‐Understandable World of Autism Spectrum Disorder: A Therapist's Implicit Understanding and Subsequent Deepened Understanding

Journal of Analytical Psychology, EarlyView.
Abstract This paper examines the concept of non‐understandable in psychotherapy, based on the author's own play therapy with a boy with mild ASD (autism spectrum disorder). ASD is considered to belong to an area beyond comprehension, as psychotherapy is often deemed ineffective for it.
Toshio Kawai
wiley   +1 more source

Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision

Journal of Cheminformatics, 2021
Rationalizing the identification of hidden similarities across the repertoire of druggable protein cavities remains a major hurdle to a true proteome-wide structure-based discovery of novel drug candidates.
Merveille Eguida, Didier Rognan
doaj   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Hémorragie méningée et hématome parenchymateux révélant une thrombose veineuse cérébrale

The Pan African Medical Journal, 2015
La thrombophlébite cérébrale (TVC) est une cause non négligeable des accidents vasculaires cérébraux avec une grande diversité de leur présentation Clinique source d'errance et de retard thérapeutique.
Toufik Joulali, Ali Derkaoui, Sophia Besri, Mohammed Malki, Abdelkarim Shimi, Mohammed Khatouf   +5 more
doaj   +1 more source

Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis

Molecules, 2020
We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a ...
Marie Ruch, Nicolas Brach, Roméric Galéa, Patrick Wagner, Gaëlle Blond   +4 more
doaj   +1 more source

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

A prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (SURECT study)

Trials, 2021
Background Although clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia, it leads to a poor or partial response in 40 to 70% of patients.
Virginie Moulier, Mohamed Wassim Krir, Marine Dalmont, SURECT Group, Olivier Guillin, Maud Rothärmel   +5 more
doaj   +1 more source

One‐Year Effectiveness of Upadacitinib in Perianal Crohn's Disease: A Real‐World GETAID Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 2, Page 235-242, July 2026.
In a real‐world cohort of patients with highly refractory perianal Crohn's disease, upadacitinib induced clinical remission at 12 months in 26% of patients with fistulizing disease and 25% of those with isolated anal ulcerations. ABSTRACT Introduction Upadacitinib (UPA) is effective for treating luminal Crohn's disease (CD), but data on perianal CD ...
Nicolas Richard, Philippe Seksik, Romain Altwegg, Maria Nachury, David Laharie, Stéphane Nancey, Benoît Coffin, Anne‐Laure Pelletier, Mathieu Uzzan, Aurélien Amiot, Morgane Amil, Lucine Vuitton, Mathurin Fumery, Anne Bozon   +13 more
wiley   +1 more source

Binding mode information improves fragment docking

Journal of Cheminformatics, 2019
Docking is commonly used in drug discovery to predict how ligand binds to protein target. Best programs are generally able to generate a correct solution, yet often fail to identify it.
Célien Jacquemard, Malgorzata N. Drwal, Jérémy Desaphy, Esther Kellenberger   +3 more
doaj   +1 more source

Luxembourg Has Spoken: Polish and Dutch Judges' Satisfaction With Rule of Law Judgements of the Court of Justice of the EU

JCMS: Journal of Common Market Studies, Volume 64, Issue 4, Page 1405-1430, July 2026.
Abstract The last decade has witnessed a substantial increase in case law of the Court of Justice of the European Union (hereafter: ECJ or Court) concerning the rule of law. This expansion in case law reflects the significant challenges to the rule of law that have arisen in recent years. Several EU member states have implemented measures that severely
Urszula Jaremba, Jasper Krommendijk
wiley   +1 more source