Results 41 to 50 of about 12,509 (121)

Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision

Journal of Cheminformatics, 2021
Rationalizing the identification of hidden similarities across the repertoire of druggable protein cavities remains a major hurdle to a true proteome-wide structure-based discovery of novel drug candidates.
Merveille Eguida, Didier Rognan
doaj   +1 more source

Psychosocial vulnerabilities and loss to follow‐up in people living with HIV in France

HIV Medicine, EarlyView.
Abstract Background Migration status is consistently associated with a higher risk of loss to follow‐up (LTFU). We investigated how sex, sexual orientation and social vulnerabilities affect the association between migration status and LTFU for hospital care in people living with HIV, using data from the ANRS CO9‐COPANA cohort linked to the nationwide ...
Charlène Mafuta, Sophie Grabar, Laurence Lievre, Cécile Goujard, Jean‐Paul Viard, Olivier Bouchaud, Laurence Meyer, Rémonie Seng, Sophie Abgrall   +8 more
wiley   +1 more source

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Hémorragie méningée et hématome parenchymateux révélant une thrombose veineuse cérébrale

The Pan African Medical Journal, 2015
La thrombophlébite cérébrale (TVC) est une cause non négligeable des accidents vasculaires cérébraux avec une grande diversité de leur présentation Clinique source d'errance et de retard thérapeutique.
Toufik Joulali, Ali Derkaoui, Sophia Besri, Mohammed Malki, Abdelkarim Shimi, Mohammed Khatouf   +5 more
doaj   +1 more source

Genèse et thématologie de Don Quichotte : l'inflexion des chapitres VI et VII

Orbis Litterarum, EarlyView.
Résumé Cet article examine la genèse de Don Quichotte à partir d'une analyse thématologique des chapitres VI et VII de la première partie, afin de réévaluer l'hypothèse critique selon laquelle l'œuvre aurait pu être initialement conçue comme un roman bref.
José Rienda Polo
wiley   +1 more source

Fatigue in multiple sclerosis: neural correlates and the role of non-invasive brain stimulation

Frontiers in Cellular Neuroscience, 2015
Multiple sclerosis (MS) is a chronic progressive inflammatory disease of the central nervous system and the major cause of non-traumatic disability in young adults.
Moussa A. Chalah, Naji eRiachi, Rechdi eAhdab, Rechdi eAhdab, Alain eCréange, Alain eCréange, Jean-Pascal eLefaucheur, Jean-Pascal eLefaucheur, Samar S. Ayache, Samar S. Ayache   +9 more
doaj   +1 more source

Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis

Molecules, 2020
We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a ...
Marie Ruch, Nicolas Brach, Roméric Galéa, Patrick Wagner, Gaëlle Blond   +4 more
doaj   +1 more source

A prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (SURECT study)

Trials, 2021
Background Although clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia, it leads to a poor or partial response in 40 to 70% of patients.
Virginie Moulier, Mohamed Wassim Krir, Marine Dalmont, SURECT Group, Olivier Guillin, Maud Rothärmel   +5 more
doaj   +1 more source

Diastereoselective Synthesis of Polysubstituted 2‐Amidino Thiolanes via Cycloaddition of N‐Thioacyl Amidines With Donor–Acceptor Cyclopropanes

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A MgBr2‐catalyzed (3+2) cycloaddition between N‐thioacyl amidines and donor–acceptor cyclopropanes provides rapid access to 2‐amidino‐thiolanes in good yields and with high diastereoselectivities. The method displays broad substrate scope and offers an efficient route to sulfur‐containing amidine scaffolds of potential biological relevance.
Laurine Tual, Thomas Cherioux, Romain Pertschi, Gaëlle Blond, Mihaela Gulea   +4 more
wiley   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2834-2852, August 2026.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source