Results 31 to 40 of about 104,379 (168)

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

open access: yesChemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas   +3 more
wiley   +1 more source

Traiter les délinquants ou contrôler les conduites : le dispositif thérapeutique à l’ère de la nouvelle pénologie

open access: yesCriminologie, 2006
RésuméDans le cadre de cet article, nous proposons d’analyser les mutations pénales à partir d’un aspect plus particulier qui est celui de la finalité thérapeutique attribuée à certaines pratiques pénales.
Bastien Quirion
doaj   +1 more source

Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways

open access: yesMolecules, 2019
Cycloadditions have emerged as some of the most useful reactions for the formation of polycyclic compounds. The carbonylative cycloaddition of triynes can lead to carbonylative and non-carbonylative competitive pathways, each leading to the formation of ...
Laura Salacz   +3 more
doaj   +1 more source

Efficacy of DOTS strategy in treatment of respiratory tuberculosis in Gorgan, Islamic Republic of Iran [PDF]

open access: yes, 2007
We carried out a follow-up cohort study of 260 smear-positive patients (178 on directly observed treatment, short-course (DOTS); 82 on non-DOTS] over a 2-year period to evaluate the efficacy of the DOTS strategy in treatment of tuberculosis (TB). All the
Abassi, A., Mansourian, A.R.
core  

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot   +8 more
wiley   +1 more source

The silent burden of anaemia in Tanzania children:a community-based study [PDF]

open access: yes, 2003
Objective was to document the prevalence, age-distribution, and risk factors for anaemia in Tanzanian children less than 5 years old,thereby assisting in the development of effective strategies for controlling anaemia.\ud \ud Cluster sampling was used to
Armstrong Schellenberg, J R M   +6 more
core   +1 more source

Divergent Synthesis of Polycyclic Derivatives via Gold Catalysis

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Gold(I)‐catalyzed cycloisomerization enables the formation of complex 3D structures from simple enyne precursors. This study presents a divergent strategy to synthesize functionalized bicyclic and tricyclic scaffolds from a common alkynyl ketone.
Emilie Gentilini   +4 more
wiley   +1 more source

Qu’est-ce qui influence le choix de la dialyse péritonéale chez les patients ? une étude qualitative.

open access: yesBulletin de la Dialyse à Domicile, 2018
L’objectif de cette étude était d’identifier les facteurs qui influencent le choix de la dialyse péritonéale (DP) chez les patients insuffisants rénaux, dans un centre de dialyse en France offrant un dispositif d’éducation thérapeutique du patient (ETP ...
Abdou Simon Senghor
doaj   +1 more source

Local recurrence and other oncologic outcomes after percutaneous image-guided tumor ablations on stageT1b renal cell carcinoma: a systematic review and network meta-analysis

open access: yesInternational Journal of Hyperthermia, 2021
Objective A systematic review of clinical trials on thermal ablation of T1b RCC was conducted to assess oncologic outcomes of those procedures. The primary endpoint was the rate of local recurrence.
Grégoire Cazalas   +7 more
doaj   +1 more source

Santiniketan: Exploration anthropologico-médicale de l'offre de soins dans un contexte de pluralisme thérapeutique. [PDF]

open access: yes, 2015
Contexte : Le processus de mondialisation en cours engendre une mise en contact de différentes cultures et, par extension de leurs systèmes médicaux, de leurs savoirs et de leurs pratiques.
SIMONIN, V.
core  

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