Results 21 to 30 of about 12,509 (121)

ABC Transporters at the Blood–Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas

Pharmaceutics, 2019
Drug delivery into the brain is regulated by the blood−brain interfaces. The blood−brain barrier (BBB), the blood−cerebrospinal fluid barrier (BCSFB), and the blood−arachnoid barrier (BAB) regulate the exchange of substances ...
David Gomez-Zepeda, Méryam Taghi, Jean-Michel Scherrmann, Xavier Decleves, Marie-Claude Menet   +4 more
doaj   +1 more source

Associations between circadian misalignment and telomere length in BD: an actigraphy study

International Journal of Bipolar Disorders, 2022
Background Life expectancy is significantly decreased in bipolar disorder (BD). This is associated with accelerated cellular aging which can be estimated by telomere length (TL). However, specific determinants of shorter TL in BD are under-explored. This
Luana Spano, Vincent Hennion, Cynthia Marie-Claire, Frank Bellivier, Jan Scott, Bruno Etain   +5 more
doaj   +1 more source

Relative Change of Protidemia Level Predicts Intradialytic Hypotension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Hemodialysis patients are at risk of intradialytic hypotension (IDH), which is associated with mortality and cardiovascular and neurological events.
Maureen Assayag, David Levy, Pascal Seris, Catherine Maheas, Anne‐Lyse Langlois, Kamal Moubakir, Sophie Laplanche, Christophe Ridel, Maxime Touzot   +8 more
doaj   +1 more source

Pregnancy‐related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas, Naim Bouazza, Frantz Foissac, Saïk Urien, Léo Froelicher‐Bournaud, Gabrielle Lui, Victoria Guillemart, Nicolas Carlier, Jennifer Da Silva, Johanna Fesenbeckh, Reem Kanaan, Isabelle Honoré, Clémence Martin, Jean‐Marc Treluyer, Vassilis Tsatsaris, Pierre‐Régis Burgel, Sihem Benaboud   +16 more
wiley   +1 more source

Traiter les délinquants ou contrôler les conduites : le dispositif thérapeutique à l’ère de la nouvelle pénologie

Criminologie, 2006
RésuméDans le cadre de cet article, nous proposons d’analyser les mutations pénales à partir d’un aspect plus particulier qui est celui de la finalité thérapeutique attribuée à certaines pratiques pénales.
Bastien Quirion
doaj   +1 more source

Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways

Molecules, 2019
Cycloadditions have emerged as some of the most useful reactions for the formation of polycyclic compounds. The carbonylative cycloaddition of triynes can lead to carbonylative and non-carbonylative competitive pathways, each leading to the formation of ...
Laura Salacz, Nicolas Girard, Jean Suffert, Gaëlle Blond   +3 more
doaj   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Methylomic biomarkers of lithium response in bipolar disorder: a clinical utility study

International Journal of Bipolar Disorders, 2023
Background Response to lithium (Li) is highly variable in bipolar disorders (BD). Despite decades of research, no clinical predictor(s) of response to Li prophylaxis have been consistently identified.
C. Marie-Claire, C. Courtin, F. Bellivier, S. Gard, M. Leboyer, J. Scott, B. Etain   +6 more
doaj   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Qu’est-ce qui influence le choix de la dialyse péritonéale chez les patients ? une étude qualitative.

Bulletin de la Dialyse à Domicile, 2018
L’objectif de cette étude était d’identifier les facteurs qui influencent le choix de la dialyse péritonéale (DP) chez les patients insuffisants rénaux, dans un centre de dialyse en France offrant un dispositif d’éducation thérapeutique du patient (ETP ...
Abdou Simon Senghor
doaj   +1 more source