Results 11 to 20 of about 12,509 (121)

An Interspecies Molecular and Functional Study of Organic Cation Transporters at the Blood-Brain Barrier: From Rodents to Humans

Pharmaceutics, 2020
Organic cation transporters (OCTs) participate in the handling of compounds in kidneys and at the synaptic cleft. Their role at the blood-brain barrier (BBB) in brain drug delivery is still unclear.
Catarina Chaves, Federica Campanelli, Hélène Chapy, David Gomez-Zepeda, Fabienne Glacial, Maria Smirnova, Meryam Taghi, Johan Pallud, Nicolas Perrière, Xavier Declèves, Marie-Claude Menet, Salvatore Cisternino   +11 more
doaj   +1 more source

Cancer du sein bilatéral synchrone: expériences du centre Mohammed VI pour le traitement des cancers CHU Ibn Rochd Casablanca

The Pan African Medical Journal, 2016
Les cancers du sein bilatéraux synchrones (CSBS) sont des maladies qui se caractérisent par une importante hétérogénéité clinique et morphologique avec une incidence entre 1,5 et 3,2%.
Ahmadaye Ibrahim Khalil, Karima Bendahhou, Houriya Mestaghanmi, Rachid Saile, Abdellatif Benider   +4 more
doaj   +1 more source

Benzylthiouracil-induced ANCA-associated Vasculitis: A Case Report and Literature Review

European Journal of Case Reports in Internal Medicine, 2019
Iatrogenic antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is not exceptional. Many cases of small vessel vasculitis induced by anti-thyroid drugs (ATD), mainly propylthiouracil (PTU), have been reported.
Fatima Bensiradj, Mathilde Hignard, Rand Nakkash, Alice Proux, Nathalie Massy, Nadir Kadri, Jean Doucet, Isabelle Landrin   +7 more
doaj   +1 more source

A multiparametric niche-like drug screening platform in acute myeloid leukemia

Blood Cancer Journal, 2022
Functional precision medicine in AML often relies on short-term in vitro drug sensitivity screening (DSS) of primary patient cells in standard culture conditions.
Reinaldo Dal Bello, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Bryann Pardieu, Paolo Ayaka, Giuseppe Di Feo, Gaetano Sodaro, Clémentine Chauvel, Rathana Kim, Loic Vasseur, Laureen Chat, Frank Ling, Kim Pacchiardi, Camille Vaganay, Jeannig Berrou, Chaima Benaksas, Nicolas Boissel, Thorsten Braun, Claude Preudhomme, Hervé Dombret, Emmanuel Raffoux, Nina Fenouille, Emmanuelle Clappier, Lionel Adès, Alexandre Puissant, Raphael Itzykson   +26 more
doaj   +1 more source

A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A

Haematologica, 2019
Rendering coagulation factor X sensitive to thrombin was proposed as a strategy that can bypass the need for factor VIII. In this paper, this non-replacement strategy was evaluated in vitro and in vivo in its ability to correct factor VIII but also ...
Toufik Abache, Alexandre Fontayne, Dominique Grenier, Emilie Jacque, Alain Longue, Anne-Sophie Dezetter, Béatrice Souilliart, Guillaume Chevreux, Damien Bataille, Sami Chtourou, Jean-Luc Plantier   +10 more
doaj   +1 more source

Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms

Journal of Nanobiotechnology, 2021
Background After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is mostly responsible for chronic infections that current therapeutics fail to cure ...
David Da Costa, Chloé Exbrayat-Héritier, Basile Rambaud, Simon Megy, Raphaël Terreux, Bernard Verrier, Charlotte Primard   +6 more
doaj   +1 more source

Expression and Purification of the Eukaryotic MBP-MOS1 Transposase from Sf21 Insect Cells

Bio-Protocol, 2014
Here, we present the full-length protocol for purifying the recombinant MOS1 transposase from insect cells used in our recent publication (Pflieger et al., 2014), which involved a N-terminal MBP-tag and maltose-affinity chromatography.
Jérôme Jaillet, Audrey Dussaussois-Montagne, Sylvaine Renault, Corinne Augé-Gouillou   +3 more
doaj   +1 more source

Neurofeedback therapy for the management of multiple sclerosis symptoms: current knowledge and future perspectives [PDF]

Journal of Integrative Neuroscience, 2021
Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Affective manifestations are also of high prevalence in this population and can drastically impact the patients’ functioning.
Samar S. Ayache, Benjamin Bardel, Jean-Pascal Lefaucheur, Moussa A. Chalah   +3 more
doaj   +1 more source

Déterminants du Suivi Médical Jusqu’à 40 Semaines Chez les Prématurés en Méthode Mère Kangourou au Cameroun : Une Étude de Cohorte

Health Research in Africa
RESUME Introduction. La Méthode Mère Kangourou (MMK) est une intervention vitale pour les prématurés, mais son bénéfice à long terme dépend d'un suivi médical régulier après la sortie de l'hôpital. Dans les pays à revenu faible et intermédiaire comme le
Ehouzou Mandeng M.N, Bilo’o Mevongo L.L, Eloundou Odi, Épée Ngoue Jeanette, Liyong Martial, Kamgaing Nelly, Kalla Ginette Claude   +6 more
doaj   +1 more source

Profil Epidémiologique, Clinique et Thérapeutique des Lésions Traumatiques des Parties Molles de la Main à Kinshasa

Health Research in Africa
RESUME Introduction. Les traumatismes des parties molles de la main représentent un motif fréquent de consultation en urgences chirurgicales, avec un impact socio-économique important, particulièrement dans les contextes urbains d'Afrique subsaharienne.
Joakim Lema-Ndomingiedi, Fanfan Milau, Getou Bungu, Stephane Kangudia-Kambala, Joseph Kabeya-Katonkola, Antoine Molua-Aundu, Matthieu Loposso-Nkumu, Luc Mokassa-Bakumobatane, Anatole Kibadi-Kapay   +8 more
doaj   +1 more source