Results 351 to 360 of about 10,836,682 (383)
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2011
CD4+ T helper (TH) lymphocytes represent a heterogeneous population of cells that play an essential role in adaptive immunity. In addition to type 1 (TH1) and type 2 (TH2) cells, a third subset of CD4+ TH effector cells have recently been discovered and named as type 17 (TH17), because of its unique ability to produce interleukin (IL)-17.
Francesco Annunziato +4 more
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CD4+ T helper (TH) lymphocytes represent a heterogeneous population of cells that play an essential role in adaptive immunity. In addition to type 1 (TH1) and type 2 (TH2) cells, a third subset of CD4+ TH effector cells have recently been discovered and named as type 17 (TH17), because of its unique ability to produce interleukin (IL)-17.
Francesco Annunziato +4 more
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Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases
Science China Life Sciences, 2020Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate.
Guan, Yang, Yaoyao, Xia, Wenkai, Ren
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Th17 cells in autoimmune diseases
Frontiers of Medicine, 2015Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases.
Lei, Han +5 more
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TH17 cells thirsty for calcium
Nature Reviews Immunology, 2019Stefan Feske and colleagues show that calcium signalling in TH17 cells promotes a pathogenic phenotype by regulating mitochondrial function and the antioxidant response.
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Th17 Cells in Cardiovascular Disease
Cell Biochemistry and FunctionABSTRACTRecent research has shown a strong link between Th17 cells and their cytokine IL‐17, and various cardiovascular diseases such as atherosclerosis, myocardial infarction, myocarditis, and arrhythmia. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease.
Ke Yang +7 more
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Blood, 2009
In this issue of Blood , Kryczek and colleagues show that a potent proinflammatory T-cell subset, IL-17–producing Th17 cells, can be found in ovarian cancers, and that their presence correlates with significantly enhanced survival.
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In this issue of Blood , Kryczek and colleagues show that a potent proinflammatory T-cell subset, IL-17–producing Th17 cells, can be found in ovarian cancers, and that their presence correlates with significantly enhanced survival.
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TH17 Cells in Fungal Infections
2011Although TH1 responses driven by the IL-12/IFN-gamma axis are central to protection against fungi, the paradigm has been revisited with two new T cell populations entering the scene: the TH17 cells involved in inflammatory responses, and the T regulatory cells (Tregs), which minimize immune responses to avoid damage to the host. While many studies have
ZELANTE, TERESA +2 more
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2014
T helper (Th)17 cells regulate host defense and exacerbate autoimmune diseases, yet their role in tumor immunity remains controversial with reports that Th17 cells could either promote or suppress tumor growth, depending on the type of malignancy or means of therapeutic intervention. This review discusses how inflammatory signals (such as cytokines and
Chrystal M. Paulos +2 more
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T helper (Th)17 cells regulate host defense and exacerbate autoimmune diseases, yet their role in tumor immunity remains controversial with reports that Th17 cells could either promote or suppress tumor growth, depending on the type of malignancy or means of therapeutic intervention. This review discusses how inflammatory signals (such as cytokines and
Chrystal M. Paulos +2 more
openaire +1 more source