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Aire functions in negative selection of self-reactive TCR during lymphocyte development through activation of tissue-restricted antigen, or TRA. This occurs specifically in the mTEC cells of the thymus, where Aire expression is generally restricted to (1) Tolerogenic signaling through Aire in the periphery was previously suggested (2).
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Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
Nature Medicine, 2013N. Komatsu +8 more
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