DOP009 Ulcerative colitis: The αEβ7 integrin is associated with a high frequency of Th17, Th1 and Th17/Th1 CD4 lymphocytes [PDF]
, 2014 Christopher A Lamb +13 more
openalex +1 more source
Th17 lymphocyte‐dependent degradation of joint cartilage by synovial fibroblasts in a humanized mouse model of arthritis and reversal by secukinumab [PDF]
, 2020 Francesca Margheri +16 more
openalex +1 more source
Clinical and Translational Science, Volume 16, Issue 1, Page 118-127, January 2023., 2023 Abstract Kidney transplantation remains the therapeutic option for patients with end‐stage kidney disease. Current immunosuppressive regimens are efficient in combating acute kidney rejection. However, insights into chronic kidney allograft injury remains limited.
Bartosz Wojciuk +6 more
wiley +1 more source
Simulating the Dynamics of T Cell Subsets Throughout the Lifetime [PDF]
arXiv, 2013 It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation of T regulatory cell (Treg) dynamics throughout the lifetime, based on a model by Baltcheva.
arxiv
Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis [PDF]
, 2020 John Davis Coakley +8 more
openalex +1 more source
Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]
, 2012 Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core +1 more source
Skin microbiome engineering: Challenges and opportunities in skin diseases treatment
iMetaOmics, EarlyView.The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley +1 more source
Clinical and Translational Science, Volume 16, Issue 1, Page 151-164, January 2023., 2023 Abstract This randomized, double‐blind, single‐ and multiple‐ascending dose study assessed the pharmacokinetics (PKs), pharmacodynamics, and safety of deucravacitinib (Sotyktu™), a selective and potent small‐molecule inhibitor of tyrosine kinase 2, in 100 (75 active, 25 placebo) healthy volunteers (NCT02534636).
Ian M. Catlett +6 more
wiley +1 more source
Numerical Investigation of Graph Spectra and Information Interpretability of Eigenvalues [PDF]
arXiv, 2015 We undertake an extensive numerical investigation of the graph spectra of thousands regular graphs, a set of random Erd\"os-R\'enyi graphs, the two most popular types of complex networks and an evolving genetic network by using novel conceptual and experimental tools.
arxiv
iMeta, EarlyView.Compared to healthy controls, children with food‐sensitized tolerance and food allergy showed reduced fecal short‐chain fatty acids (SCFAs), particularly butyrate. In an ovalbumin‐sensitized mouse model, butyrate outperformed other SCFAs in alleviating allergic responses.
Jialu Shi +11 more
wiley +1 more source